Risk of Testosterone Flare in the Era of the Saturation Model: One More Historical Myth.

Abstract

CONTEXT When luteinizing hormone-releasing hormone (LHRH) agonists were introduced in the 1980s, it was universally believed that the initial transient rise in serum testosterone (T), termed T flare, caused rapid prostate cancer (PCa) growth and led to disease progression, complications, and death. It became routine to offer antiandrogens (AAs) to prevent… (More)
DOI: 10.1016/j.euf.2017.06.008

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