Risk of Heart Failure With Preserved Ejection Fraction in Older Women After Contemporary Radiotherapy for Breast Cancer.

@article{Saiki2017RiskOH,
  title={Risk of Heart Failure With Preserved Ejection Fraction in Older Women After Contemporary Radiotherapy for Breast Cancer.},
  author={Hirofumi Saiki and Ivy A. Petersen and Christopher G Scott and Kent R. Bailey and Shannon M. Dunlay and Randi R. Finley and Kathryn J Ruddy and Elizabeth S Y Yan and Margaret May Redfield},
  journal={Circulation},
  year={2017},
  volume={135 15},
  pages={
          1388-1396
        }
}
BACKGROUND Cardiomyocytes are resistant to radiation. However, cardiac radiation exposure causes coronary microvascular endothelial inflammation, a perturbation implicated in the pathogenesis of heart failure (HF) and particularly HF with preserved ejection fraction (HFpEF). Radiotherapy for breast cancer results in variable cardiac radiation exposure and may increase the risk of HF. METHODS We conducted a population-based case-control study of incident HF in 170 female residents of Olmsted… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Similar Papers

Loading similar papers…