Risk of Fractures Requiring Hospitalization After an Initial Prescription for Zolpidem, Alprazolam, Lorazepam, or Diazepam in Older Adults

@article{Finkle2011RiskOF,
  title={Risk of Fractures Requiring Hospitalization After an Initial Prescription for Zolpidem, Alprazolam, Lorazepam, or Diazepam in Older Adults},
  author={William D. Finkle and Jane S Der and Sander Greenland and John L. Adams and Gregory K. Ridgeway and Terrance Blaschke and Zixia Wang and Richard M. Dell and K Vanriper},
  journal={Journal of the American Geriatrics Society},
  year={2011},
  volume={59}
}
To determine whether zolpidem is a safer alternative to benzodiazepines. 
Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs): a methodological approach to assess consistencies across databases from the PROTECT‐EU project
Results from observational studies may be inconsistent because of variations in methodological and clinical factors that may be intrinsically related to the database (DB) where the study is performed.
Correlation Between Use of Zopiclone and Risk of Hip Fracture in Elderly Adults: A Case–Control Study in Taiwan
TLDR
To investigate the correlation between zopiclone use and risk of hip fracture in elderly adults, a large number of patients with a history of hip injury or disfigurement were surveyed.
Risks associated with long-term benzodiazepine use.
TLDR
Many patients underestimate the degree of impairment caused by benzodiazepines, and the risk of overdose is particularly great when combined with sedative drugs such as opioids or alcohol.
Potentially inappropriate medicines in a cohort of community‐dwelling older people in New Zealand
TLDR
To examine independent factors associated with potentially inappropriate medicines (PIM) among 316 community‐dwelling people aged ≥75 years living in Dunedin, a large number of people thought to be suitable for use in clinical practice have not been identified.
Concomitant use of benzodiazepines and opioids in community‐dwelling older people with or without Alzheimer's disease—A nationwide register‐based study in Finland
The study aims to determine the prevalence of concomitant use of benzodiazepines and opioids among community‐dwelling older people with or without Alzheimer's disease (AD). An additional aim was to
Reducing Benzodiazepine Prescribing in Older Veterans: A Direct-to-Consumer Educational Brochure.
This quality improvement project used an educational brochure to help older veterans reduce their benzodiazepine use.
All Worked Up About the Evidence: Valproate for Agitation in Dementia
TLDR
Learning objectives: Describe the epidemiology and etiology of dementia and associated behavioral and psychological symptoms and formulate an evidence-based recommendation regarding valproate use.
Dependence, misuse, and beliefs regarding use of hypnotics by elderly psychiatric patients taking zolpidem, estazolam, or flunitrazepam
  • C. Yen, C. Ko, +5 authors Cheng-Sheng Chen
  • Psychology, Medicine
    Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists
  • 2015
To examine the prevalence rates and correlates of dependence on, misuse of, and beliefs regarding use of hypnotics in elderly psychiatric patients with long‐term use of zolpidem, estazolam, or
Zolpidem use and risk of fractures: a systematic review and meta-analysis
TLDR
Clinicians should be cautious when prescribing zolpidem for patients at high risk of fracture, and high-quality subgroups (cohort studies, high NOS score, adjusted for any confounder, or adjusted for osteoporosis) had higher RRs than the corresponding low- quality subgroups.
Benzodiazepines, Z-drugs and the risk of hip fracture: A systematic review and meta-analysis
TLDR
There is strong evidence that both BNZ and Z-drugs are associated with an increased risk of hip fracture in the older person, and there is little difference between their respective risks.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 52 REFERENCES
Zolpidem Use and Hip Fractures in Older People
TLDR
Although benzodiazepines have been shown to increase fall and fracture risk, zolpidem, a nonbenzodiazepine hypnotic, has been advocated as a safer alternative.
Drugs and Falls in Older People: A Systematic Review and Meta‐analysis: I. Psychotropic Drugs
TLDR
To evaluate critically the evidence linking psychotropic drugs with falls in older people, a large number of studies have found no link between these drugs and falls in adults over the age of 65.
Claims Data Studies of Sedative‐Hypnotics and Hip Fractures in Older People: Exploring Residual Confounding Using Survey Information
TLDR
To identify the magnitude of confounding bias caused by factors not measured in claims data studies of sedative‐hypnotic use and fractures, a large number of studies found it to be higher than expected.
Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage, and duration on risk of hip fracture.
TLDR
Even at modest doses, including some low doses currently advocated in prescribing guidelines for older patients, treatment with benzodiazepines appears to increase the risk of hip fracture and patients appear to be particularly vulnerable immediately after initiating therapy and after more than 1 month of continuous use.
Benzodiazepines and the risk of falling leading to femur fractures. Dosage more important than elimination half-life.
TLDR
Benzodiazepines are a major, independent risk factor for falls leading to femur fractures, and the increased risk is probably explained by prescribing too-high doses to the elderly.
Psychotropic drug use and the risk of hip fracture.
TLDR
The hypothesis that the sedative and autonomic effects of psychotropic drugs increase the risk of falling and fractures in elderly persons is supported and the need for studies of this association in other populations is suggested.
Benzodiazepines of long and short elimination half-life and the risk of hip fracture.
TLDR
Medical record review for a sample of 189 cases suggested that this finding was not due to confounding by dementia, ambulatory status, functional status, or body mass, and it was not altered by sex, age, calendar year, nursing home residence, or history of hospitalization.
Benzodiazepine tranquilizers and the risk of accidental injury.
TLDR
Accident-related care was more likely among persons who had been prescribed benzodiazepines and those who had filled three or more prescriptions for these agents in the six months following initiation of therapy had a significantly higher risk of an accident-related medical event.
Influence of Zolpidem and Sleep Inertia on Balance and Cognition During Nighttime Awakening: A Randomized Placebo‐Controlled Trial
TLDR
To determine whether sleep inertia (grogginess upon awakening from sleep) with or without zolpidem impairs walking stability and cognition during awakenings from sleep, a network of rats is studied.
Occupational injuries and medication use.
TLDR
The use of some medications, or conditions requiring medications, may contribute to the risk of a work-related injury, and the patterns of risk were similar for males and females, but varied by type of injury.
...
1
2
3
4
5
...