Risk of Diabetes Mellitus Associated with Atypical Antipsychotic Use Among Medicaid Patients with Bipolar Disorder: A Nested Case‐Control Study

@article{Guo2007RiskOD,
  title={Risk of Diabetes Mellitus Associated with Atypical Antipsychotic Use Among Medicaid Patients with Bipolar Disorder: A Nested Case‐Control Study},
  author={Jeff Jianfei Guo and Paul E. Keck and Patricia K Corey-Lisle and Hong Li and Dongming Jiang and Raymond Jang and Gilbert J. L’italien},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2007},
  volume={27}
}
  • J. GuoP. Keck G. L’italien
  • Published 1 January 2007
  • Medicine, Psychology
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Study Objective. To quantify the risk of diabetes mellitus associated with atypical antipsychotics compared with conventional antipsychotics in managed care Medicaid patients with bipolar disorder. 

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A final important source of cardiometabolic risk in major mental disorders is treatment itself although before the introduction of the antipsychotic drugs it was acknowledged that patients with schizophrenia and bipolar disorder may be at a higher risk of abnormal glucose metabolism and metabolic disorders compared to general population.

Reaching for wellness in schizophrenia.

Schwere psychische Erkrankungen und Diabetes mellitus Typ-2

Prevalence rates of DM type 2 as well as important individual lifestyle choices and side effects of antipsychotic and antidepressant treatment are reported, which each account for much of the increased risk of this metabolic disease in patients with severe mental illness.

Bipolar Disorder and Weight Gain: A Multifactorial Assessment

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Primary care issues in patients with mental illness.

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Treatment of Co-Morbid Mental Illness in Primary Care: How to Minimize Weight Gain, Diabetes, and Metabolic Syndrome

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References

SHOWING 1-10 OF 59 REFERENCES

Antipsychotic exposure and type 2 diabetes among patients with schizophrenia: a matched case‐control study of California Medicaid claims

To examine the risk of developing type 2 diabetes mellitus among people with schizophrenia exposed to atypical antipsychotics (clozapine, olanzapine, quetiapine, risperidone) compared to those

Risperidone‐Associated Diabetes Mellitus: A Pharmacovigilance Study

The objective is to explore the clinical characteristics of hyperglycemia in patients treated with risperidone and to find out whether these characteristics can be improved with further treatment.

Diabetes as a result of atypical anti‐psychotic drugs – a report of three cases

  • V. RigalleauB. Gatta H. Gin
  • Medicine, Psychology
    Diabetic medicine : a journal of the British Diabetic Association
  • 2000
Aims  Atypical anti‐psychotic drugs (APDs) are widely used in psychotic disorders refractory to conventional neuroleptic agents.

Treatment of bipolar disorder∗

The current status of the management of bipolar disorder (manic‐depressive illness) is reviewed with a focus on hospital admissions and treatment regimens.

Incidence of New-Onset Diabetes Mellitus Among Patients Receiving Atypical Neuroleptics in the Treatment of Mental Illness: Evidence From a Privately Insured Population

Diabetes risk was significantly lower among males receiving risperidone or quetiapine, while diabetes risk among females did not differ significantly from first-generation antipsychotics for any atypical examined, substantially different from other reports.

Clozapine use in patients with schizophrenia and the risk of diabetes, hyperlipidemia, and hypertension: a claims-based approach.

Data suggest that clozapine may not be an independent cause of diabetes or hyperlipidemia, but instead acts as an effect modifier in susceptible populations by increasing weight or affecting insulin secretion and resistance.

Hyperglycemia associated with the use of atypical antipsychotics.

These studies indicate that hyperglycemia is not dose dependent, is reversible on cessation of treatment with clozapine or olanzapine, and reappears on reintroduction of these therapies.

Incident diabetes associated with antipsychotic use in the United Kingdom general practice research database.

This study showed an increased risk of incident diabetes among current users of atypical and conventional antipsychotic medications, independent of other established risk factors.

Assessment of independent effect of olanzapine and risperidone on risk of diabetes among patients with schizophrenia: population based nested case-control study

Patients taking olanzapine are associated with a clinically important and significant increased risk of diabetes and non-users of antipsychotics are not affected.

Incidence of newly diagnosed diabetes attributable to atypical antipsychotic medications.

The proportion of patients with schizophrenia with a stable regimen of antipsychotic monotherapy who developed diabetes or were hospitalized for ketoacidosis was determined and clozapine and olanzapine have greater diabetes risk, but the attributable risk of diabetes mellitus with atypical antipsychotics is small.
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