Risk of Depression Associated With Finasteride Treatment

@article{Pompili2021RiskOD,
  title={Risk of Depression Associated With Finasteride Treatment},
  author={Maurizio Pompili and Carlo Magistri and Stefano Maddalena and Cristiano Mellini and Severino Persechino and Ross J. Baldessarini},
  journal={Journal of Clinical Psychopharmacology},
  year={2021},
  volume={41},
  pages={304 - 309}
}
Abstract Background Finasteride is one of several inhibitors of the 5α-reductase that converts testosterone to dihydrotestosterone used to treat hair loss and benign prostatic enlargement. Emerging clinical observations indicate that such treatment may be associated with depression, anxiety, and possibly increased suicidal risks, in addition to sexual dysfunction, even after its discontinuation. Methods We carried out a systematic review of reports pertaining to association of finasteride… 
3 Citations
Systematic review: depression, suicidal ideation with finasteride
  • Psychology, Medicine
    Reactions Weekly
  • 2021
TLDR
Findings provide tentative support for increased suicidal risk in association with finasteride treatment, and suggest "prospective and ideally randomized and placebo-controlled trials would be helpful in testing the risks of depression and suicidal status", note the authors.
Further Studies of Effects of Finasteride on Mood and Suicidal Risk.

References

SHOWING 1-10 OF 57 REFERENCES
Finasteride induced depression: a prospective study
TLDR
This preliminary study suggests that finasteride might induce depressive symptoms; therefore this medication should be prescribed cautiously for patients with high risk of depression.
Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride
Finasteride is a synthetic 5-α reductase inhibitor, which prevents the conversion of testosterone to dihydrotestosterone and has been used for more than 20 years in the treatment of male pattern hair
Depression Circumstantially Related to the Administration of Finasteride for Androgenetic Alopecia
TLDR
Depression, which significatively impaired sociofamilial relations, sleep and eating behaviour, was associated to marked anxiety in some cases, developed after 9–19 weeks of treatment with finasteride, and promptly resolved after suspension of the drug.
Association of Suicidality and Depression With 5&agr;-Reductase Inhibitors
TLDR
In a large cohort of men ages 66 years or older, an increased risk of suicide associated with 5&agr;-reductase inhibitor use was not demonstrated, however, the risk of self-harm and depression were increased compared with unexposed men.
Emotional Consequences of Finasteride: Fool’s Gold
TLDR
Results provide evidence on the need to screen for psychiatric history and counseling patients about the potential psychological consequences of finasteride, and prescribing clinicians should carefully weigh the risk/benefit ratio with these patients.
Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review.
TLDR
A literature search reviewing adverse events of 5-alpha reductase inhibitors as they relate to prostate cancer, psychological effects, sexual health, and use in women found they were well-tolerated in both men and women, but not without risk.
Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients
Research Brief: Self-Reports of a Constellation of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men
TLDR
This research objective is to understand more, through subjective, self-reports on discussion boards/forums, persons’ experiences associated with the use of drugs that alter androgen metabolism, such as finasteride, to engender greater understanding of the perceived lasting AEs of Finasteride.
Post-finasteride syndrome: a surmountable challenge for clinicians.
  • A. Traish
  • Medicine, Psychology
    Fertility and sterility
  • 2020
...
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