Risk of Creutzfeldt–Jakob disease transmission by ocular surgery and tissue transplantation

@article{Armitage2009RiskOC,
  title={Risk of Creutzfeldt–Jakob disease transmission by ocular surgery and tissue transplantation},
  author={W John Armitage and Andrew B Tullo and James W Ironside},
  journal={Eye},
  year={2009},
  volume={23},
  pages={1926-1930}
}
Creutzfeldt–Jakob disease (CJD) is a rare, fatal neurodegenerative disease that occurs in sporadic, genetic, variant, and iatrogenic forms. The transformation of normal prion protein (PrPC) to the abnormal form (PrPSc) is a key step in the pathogenesis of CJD and leads to the accumulation of amyloid and spongiform changes in the brain. The presence of PrPSc in tissue is a surrogate marker for CJD infectivity. Sporadic CJD, whose cause is unknown, is by far the most frequent form with 1–2 cases… CONTINUE READING
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