Risk of Anal Cancer in a Cohort With Human Papillomavirus–Related Gynecologic Neoplasm

  title={Risk of Anal Cancer in a Cohort With Human Papillomavirus–Related Gynecologic Neoplasm},
  author={Abdulaziz M. Saleem and Jessica K. Paulus and A P Shapter and Nancy N. Baxter and Patricia L. Roberts and Rocco Ricciardi},
  journal={Obstetrics \& Gynecology},
OBJECTIVE: To assess the development of anal cancer in women diagnosed with a human papillomavirus–related cervical, vulvar, or vaginal neoplasm. METHODS: Using data from National Cancer Institute's Surveillance, Epidemiology and End Results program from 1973 through 2007, 189,206 cases with either in situ or invasive cervical, vulvar, or vaginal neoplasm were followed for 138,553,519 person-years for the development of subsequent primary anal cancer. Standardized incidence ratios were… 
Risk of Anal Cancer in Women With a Human Papillomavirus–Related Gynecological Neoplasm: Puerto Rico 1987–2013
Anal cancer is increasing among women in Puerto Rico, and women with gynecological HPV-related tumors are at higher risk of secondary anal cancer as compared with women from the general population and with those with non–HPV-related Gynecological cancers.
Anal Cancer and Anal Cancer precursors in Women with a History of HPV-Related Dysplasia and Cancer.
The prevalence of anal high grade squamous intraepithelial lesions (HSIL) in this population was relatively low, which may have been related to the fact that many of these studies had insufficient samples, and the numbers of patients undergoing HRA remain low.
New Insights into the Role of Human Papillomavirus in Anal Cancer and Anal Wart Development
The large majority of anal cancers are squamous cell carcinomas (SCC), and around 90% are attributed to human papillomavirus, which seems to have a prognostic value, with better survival in those patients with positive tumors.
The epidemiology of anal cancer.
Case-control studies have demonstrated that sexual risk factors (homosexuality in men and multiple sexual partners in women) are strongly associated with anal cancer risk, and vaccination against HPV holds great promise for anal cancer prevention for those not already HPV-infected.
Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia
This study supports the hypothesis of an increased risk of HPV-related tumours for Cin treated patients, mostly for CIN3 and suggests the need of early diagnosis for these cancers in this higher-risk populations.
Risk of second HPV-associated cancers in men with penile cancer
It is indicated that men with penile cancer are at an increased risk of a second HPV-associated cancer of the oral cavity, oropharynx and anal canal.
Risk Factors for Anal Dysplasia among Privately Insured HIV-Negative Women
HIV-negative women with anal dysplasia are more likely to have concomitant human papillomavirus (HPV)-related CIN and anogenital warts than women without anal Dysplasia and could benefit from anal dysPlasia/anal cancer screening.
Screening for Anal Cancer in Women
While there are no data yet to demonstrate that identification and treatment of anal HSIL leads to reduced risk of anal cancer, women in groups at the highest risk should be queried for anal cancer symptoms and required to have digital anorectal examinations to detect anal cancers.


Second primary cancer after in situ and invasive cervical cancer.
Standardized incidence ratios were elevated after both in situ and invasive cervical cancer for cancers of the upper aerodigestive tract, anus, pancreas, lung, other female genitals, and urinary bladder, and smoking appeared to be the major cause among the remaining sites.
Human papillomavirus infection as a risk factor for anal and perianal skin cancer in a prospective study
Prospective epidemiological evidence of an association between infection with HPV 16 and 18 and anal and perianal skin cancer is provided and the highest risks were seen for HPV 16 seropositive patients above the age of 45 years at serum sampling and for patients with a lag time of less than 10 years.
[Sexually transmitted infection as a cause of anal cancer].
It is concluded that most anal cancers appear to be caused by sexually transmitted types of human papillomaviruses and, consequently, that anal cancer is a potentially preventable neoplasm.
Second cancers among 104,760 survivors of cervical cancer: evaluation of long-term risk.
Cervical cancer patients treated with radiotherapy are at increased risk for all second cancers and cancers at heavily irradiated sites beyond 40 years of follow-up compared with women in the general population.
Screening for cancer of the cervix uteri
  • E. Lynge
  • Medicine
    World Journal of Surgery
  • 2005
Computerized pathology registration systems may serve as a tool for integration of the total smear-taking activity and, thus, ensure that a high percentage of women are screened regularly at minimized costs.
Human papillomavirus 16 and 18 L1 serology compared across anogenital cancer sites.
Differences in the proportion of seropositives among HPV-16 DNA-positive cases by site suggest either that the immune response varies by site or that cancer development may lead to changes in antibody responses in a site-specific fashion.