Risk of Anal Cancer in a Cohort With Human Papillomavirus–Related Gynecologic Neoplasm

@article{Saleem2011RiskOA,
  title={Risk of Anal Cancer in a Cohort With Human Papillomavirus–Related Gynecologic Neoplasm},
  author={Abdulaziz M. Saleem and Jessica K. Paulus and A P Shapter and Nancy N. Baxter and Patricia L. Roberts and Rocco Ricciardi},
  journal={Obstetrics \& Gynecology},
  year={2011},
  volume={117},
  pages={643-649}
}
OBJECTIVE: To assess the development of anal cancer in women diagnosed with a human papillomavirus–related cervical, vulvar, or vaginal neoplasm. METHODS: Using data from National Cancer Institute's Surveillance, Epidemiology and End Results program from 1973 through 2007, 189,206 cases with either in situ or invasive cervical, vulvar, or vaginal neoplasm were followed for 138,553,519 person-years for the development of subsequent primary anal cancer. Standardized incidence ratios were… 
Risk of Anal Cancer in Women With a Human Papillomavirus–Related Gynecological Neoplasm: Puerto Rico 1987–2013
TLDR
Anal cancer is increasing among women in Puerto Rico, and women with gynecological HPV-related tumors are at higher risk of secondary anal cancer as compared with women from the general population and with those with non–HPV-related Gynecological cancers.
Anal Cancer and Anal Cancer precursors in Women with a History of HPV-Related Dysplasia and Cancer.
TLDR
The prevalence of anal high grade squamous intraepithelial lesions (HSIL) in this population was relatively low, which may have been related to the fact that many of these studies had insufficient samples, and the numbers of patients undergoing HRA remain low.
New Insights into the Role of Human Papillomavirus in Anal Cancer and Anal Wart Development
TLDR
The large majority of anal cancers are squamous cell carcinomas (SCC), and around 90% are attributed to human papillomavirus, which seems to have a prognostic value, with better survival in those patients with positive tumors.
The epidemiology of anal cancer.
TLDR
Case-control studies have demonstrated that sexual risk factors (homosexuality in men and multiple sexual partners in women) are strongly associated with anal cancer risk, and vaccination against HPV holds great promise for anal cancer prevention for those not already HPV-infected.
Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia
TLDR
This study supports the hypothesis of an increased risk of HPV-related tumours for Cin treated patients, mostly for CIN3 and suggests the need of early diagnosis for these cancers in this higher-risk populations.
Risk of second HPV-associated cancers in men with penile cancer
TLDR
It is indicated that men with penile cancer are at an increased risk of a second HPV-associated cancer of the oral cavity, oropharynx and anal canal.
Risk Factors for Anal Dysplasia among Privately Insured HIV-Negative Women
TLDR
HIV-negative women with anal dysplasia are more likely to have concomitant human papillomavirus (HPV)-related CIN and anogenital warts than women without anal Dysplasia and could benefit from anal dysPlasia/anal cancer screening.
Screening for Anal Cancer in Women
TLDR
While there are no data yet to demonstrate that identification and treatment of anal HSIL leads to reduced risk of anal cancer, women in groups at the highest risk should be queried for anal cancer symptoms and required to have digital anorectal examinations to detect anal cancers.
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