Risk of Alzheimer's disease biological misdiagnosis linked to cerebrospinal collection tubes.

  title={Risk of Alzheimer's disease biological misdiagnosis linked to cerebrospinal collection tubes.},
  author={Armand Perret-Liaudet and Mathieu Pelpel and Yannick Tholance and Beno{\^i}t Dumont and Hugo Marcel Johan Vanderstichele and Willy Zorzi and Benaissa Elmoualij and Susanna Schraen and O. Moreaud and Audrey Gabelle and Eric Thouvenot and C. Thomas-Ant{\'e}rion and Jacques Touchon and P. Krolak-Salmon and Gabor G Kovacs and Arnaud Coudreuse and Isabelle Quadrio and Sylvain Lehmann},
  journal={Journal of Alzheimer's disease : JAD},
  volume={31 1},
Tau proteins and amyloid-β (Aβ) peptides are the current recognized cerebrospinal fluid (CSF) biomarkers used as an aid in the diagnosis of Alzheimer's disease (AD). However, there is no consensus on their clinical use due to non-qualified cut-off values, probably related to the observed high pre-analytical and analytical variability. Standardized pre-analytical protocols have therefore been proposed. Importantly, these recommend the use of polypropylene collection/sampling tubes while, to date… CONTINUE READING


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/ Alzheimer ’ s Disease Biological Misdiagnosis peptide ratio 42 / 40 but not A beta 42 correlates with phospho - tau in patients with low - and high - CSF A beta 40 load

  • B Dubois, HH Feldman, +21 authors P Scheltens
  • J Neurochem
  • 2010

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