Risk-group-specific dose finding based on an average toxicity score.


We propose a Bayesian dose-finding design that accounts for two important factors, the severity of toxicity and heterogeneity in patients' susceptibility to toxicity. We consider toxicity outcomes with various levels of severity and define appropriate scores for these severity levels. We then use a multinomial-likelihood function and a Dirichlet prior to… (More)
DOI: 10.1111/j.1541-0420.2009.01297.x