Risk for Asthma in 1-Year-Old Infants Residing in New York City High-Risk Neighborhoods

  title={Risk for Asthma in 1-Year-Old Infants Residing in New York City High-Risk Neighborhoods},
  author={Ilan H. Meyer and Robin M. Whyatt and Frederica P. Perera and Jean G. Ford},
  journal={Journal of Asthma},
  pages={545 - 550}
Morbidity and mortality resulting from asthma has increased in the United States and across the world in the past few decades (1). For example, hospitalization among persons ages 0–24 years has increased by 27% between 1980 and 1993 (from 16.8 to 21.4 per 10,000 persons), with the highest increases in hospitalization associated with the youngest ages (2,3). Respiratory symptoms resembling asthma tend to be present early in life (4) but asthma is not usually diagnosed until a later age (5… 
5 Citations

Racial Disparities in Childhood Asthma in the United States: Evidence From the National Health Interview Survey, 1997 to 2003

Black children are more likely to have asthma and to experience ED visits for asthma, compared with otherwise comparable white children, and these racial disparities cannot be explained by differences in measurable child or family characteristics.

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Despite a substantially higher prevalence of asthma in the Northern Manhattan community compared with other areas, total IgE levels at ages 24 and 36 months, but not cord blood, are similar to those reported in other areas of the world.

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Mediators of inflammation in the early and the late phase of allergic rhinitis

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Total arsenic concentrations in toenails quantified by two techniques provide a useful biomarker of chronic arsenic exposure in drinking water and influence the developmental toxicity of TCDD.



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An algorithm is presented that outlines possible criteria to determine the risk of developing asthma in infants and shows that infants who subsequently develop asthma in childhood have higher serum immunoglobulin E (IgE) and peripheral eosinophil counts than those who do not develop asthma.

A clinical index to define risk of asthma in young children with recurrent wheezing.

It is concluded that the subsequent development of asthma can be predicted with reasonable accuracy using simple, clinically based parameters.

Early respiratory infections and childhood asthma.

Early respiratory infections indicate increased, rather than decreased, risk of developing bronchial obstruction during the first 2 years of life and of having asthma at 4 years of age.

A community-based study of the epidemiology of asthma. Incidence rates, 1964-1983.

It is concluded that asthma begins in early childhood, with a higher incidence and earlier onset in males, and that the increase in incidence rates seen from 1964 to 1983 occurred only in children and in adolescents.

Asthma and wheezing in the first six years of life. The Group Health Medical Associates.

Children who started wheezing in early life and continued to wheeze at the age of six were more likely than the children who never wheezed to have mothers with a history of asthma, but do not have increased risks of asthma or allergies later in life.


The majority of infants with wheeze have transient conditions associated with diminished airway function at birth and do not have increased risks of asthma or allergies later in life, but in a substantial minority of infants, however, wheezing episodes are probably related to a predisposition to asthma.

Wheezing in early life and asthma at school age: Predictors of symptom persistence

Among all wheezy children younger than 3 years, those who have a history of food allergy, itchy rash, asthma occurrence in a sibling or parent, or are exposed to tobacco smoke during the first years of life are at highest risk for symptom persistence until school age.

Predictors of repeated wheeze in the first year of life: the relative roles of cockroach, birth weight, acute lower respiratory illness, and maternal smoking.

It is unknown whether the association between cockroach and repeated wheeze in infancy represents a cockroach-related increased risk of bronchial inflammation through nonallergenic or allergenic mechanisms.

Childhood- versus adult-onset asthma.

Data suggest that airway responsiveness, respiratory symptoms, and peripheral blood eosinophilia are independent risk factors for the develop­ ment of chronic obstructive disease and that the mechanism by which these factors predict this development is by reducing max­ imallung function and precipitating early decline in FE~ in young adults.

ASTHMA PHENOTYPES : Wheezy Infants and Wheezy Children