Risk factors for the development of clinical leprosy among contacts, and their relevance for targeted interventions.

@article{Moet2004RiskFF,
  title={Risk factors for the development of clinical leprosy among contacts, and their relevance for targeted interventions.},
  author={F Johannes Moet and Abraham Meima and Linda Oskam and Jan Hendrik Richardus},
  journal={Leprosy review},
  year={2004},
  volume={75 4},
  pages={
          310-26
        }
}
Existing knowledge on risk factors for the development of clinical leprosy among contacts of known leprosy patients is reviewed with the aim to identify factors associated with leprosy among contacts that have potential for developing effective targeted interventions in leprosy control. Different definitions of 'contact' have been used and most studies on this subject were among so-called household members. Yet several studies indicate that contacts found in other places than the household are… 
Physical distance, genetic relationship, age, and leprosy classification are independent risk factors for leprosy in contacts of patients with leprosy.
TLDR
Age of the contact, the disease classification of the index patient, and physical and genetic distance were independently associated with the risk of a contact acquiring leprosy.
Duration of Contact, Type of Leprosy, And Floor Condition As Risk Factors For Leprosy Sero-positivity
TLDR
The findings indicated that not only the duration of leprosy and the contacts need to be considered in the transmission ofLeprosy, but also environmental factors, such as the subjects’ house floor condition, are needed.
Patients with skin smear positive leprosy in Bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (COCOA)
TLDR
A dominance of a single variable predicting risk for leprosy transmission–skin smear positive index cases is found and the administration of single-dose rifampicin to household contacts as the sole intervention in Bangladesh will not be effective.
A study on transmission and a trial of chemoprophylaxis in contacts of leprosy patients: design, methodology and recruitment findings of COLEP.
TLDR
The design, methodology and recruitment findings of the COLEP study, a large field trial to determine the effectiveness of chemoprophylaxis with a single dose of rifampicin in the prevention of leprosy among close contacts ofLeprosy patients, and to find characteristics of contact groups most at risk to develop clinical leproSy are described.
Risk factors associated with illness in leprosy contacts: a systematic review protocol
TLDR
Monitoring contacts is one of the most effective strategies for leprosy control and the identification of risk factors for illness in contacts can contribute to the development of actions in public health.
Close contacts with leprosy in newly diagnosed leprosy patients in a high and low endemic area: comparison between Bangladesh and Thailand.
TLDR
It is indicated that in a low endemic area a higher proportion of newly detected leprosy cases have a family history of leproSy compared to a high endemic area.
Risk factor for Mycobacterium leprae detection in household contacts with leprosy patients: a study in Papua, East Indonesia
BACKGROUND In the era of leprosy eradication, Jayapura is still one of the biggest leprosy pockets in Papua, Indonesia. The trend for leprosy case detection rate has remained relatively stable over
Effectiveness of rifampicin chemoprophylaxis in preventing leprosy in patient contacts: a systematic review of quantitative and qualitative evidence
TLDR
Chemoprophylaxis with one dose of rifampicin is found to be effective in preventing contacts of leprosy patients from contracting the disease and there is indication that this strategy is socially accepted.
Factors associated with the development of leprosy in contacts: a systematic review and meta-analysis.
TLDR
Leprosy in contacts of patients involves social determination, individual susceptibility, and difficulties in access to disease control actions, but modifiable risk factors are the main determinants of illness in this population.
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