Risk factors for nephrotoxicity in patients receiving outpatient continuous infusions of vancomycin in an Australian tertiary hospital.

@article{Norton2014RiskFF,
  title={Risk factors for nephrotoxicity in patients receiving outpatient continuous infusions of vancomycin in an Australian tertiary hospital.},
  author={Katherine Norton and Paul Robert Ingram and Christopher H. Heath and Laurens Manning},
  journal={The Journal of antimicrobial chemotherapy},
  year={2014},
  volume={69 3},
  pages={805-8}
}
OBJECTIVES To assess the risk factors for nephrotoxicity caused by vancomycin continuous infusion in a predominantly Caucasian outpatient population. METHODS This was a retrospective cohort study of 155 patient episodes from December 2006 to December 2011. RESULTS Vancomycin-associated nephrotoxicity (VN) occurred in 26 of 155 (17%) patient episodes. After adjustment for baseline renal function, maximum steady-state vancomycin concentrations ≥32 mg/L [OR 8.7 (95% CI 3.1-29.6), P < 0.001… CONTINUE READING