Risk factors for invasive squamous cell carcinoma of the vulva and vagina—Population‐based case–control study in Denmark

  title={Risk factors for invasive squamous cell carcinoma of the vulva and vagina—Population‐based case–control study in Denmark},
  author={Birgitte Schütt Madsen and Helle L. Jensen and Adriaan J. C. van den Brule and Jan Wohlfahrt and Morten Frisch},
  journal={International Journal of Cancer},
The etiology of vulvar and vaginal squamous cell carcinoma (VV‐SCC) has received little attention. A total of 182 women with invasive VV‐SCC (116 with VV‐SCCvulva, 66 with VV‐SCCvagina), 164 uterine corpus cancer controls and 518 population controls were interviewed in a population‐based case–control study in Denmark, and 87 (48%) of the VV‐SCC cases had tissue samples examined for human papillomavirus (HPV) DNA using the GP5+/6+ PCR‐EIA assay and subsequent reverse line blotting for HPV typing… 

Risk Factors for Squamous Cell Carcinoma of the Penis—Population-Based Case-Control Study in Denmark

This study confirms sexually transmitted HPV16 infection and phimosis as major risk factors for penile SCC and suggests that penile-oral sex may be an important means of viral transmission, and confirms the association with priapism was unexpected and needs replication.

Prevalence and type distribution of human papillomavirus in squamous cell carcinoma and intraepithelial neoplasia of the vulva

HPV vaccination targeting these HPV types may prevent a substantial number of vulvar lesions, and the predominant high‐risk HPV type was HPV16, followed by HPV33 and HPV18.

Histological characteristics of human papilloma‐virus‐positive and ‐negative invasive and in situ squamous cell tumours of the penis

About half of invasive penile squamous carcinomas in this study were hrHPV‐positive, most notably to HPV 16, and probably arose through in situ lesions whereas the other half ofvasive penile lesions appeared to be unrelated tohrHPV.

Human papillomavirus and p16 in squamous cell carcinoma and intraepithelial neoplasia of the vagina

It is suggested that vaccination against HPV might prevent a substantial proportion of vaginal neoplasia and highlight the need for further studies of the possible clinical value of p16 testing in these patients.

Large contribution of human papillomavirus in vaginal neoplastic lesions: a worldwide study in 597 samples.

Searching beyond the usual papillomavirus suspects in squamous carcinomas of the vulva, penis and head and neck.

Presence of human papillomavirus (HPV) in vulvar squamous cell carcinoma (VSCC) and sentinel node.




Human Papillomavirus Type 16 and Risk of Preinvasive and Invasive Vulvar Cancer: Results From a Seroepidemiological Case‐control Study

It is confirmed that HPV is associated with vulvar carcinomas and the possibility that other sexually transmitted agents might be involved in the etiology of some vulvar tumors is suggested, and it is suggested that smoking may be an important cofactor involved in this disease process.

Cofactors with human papillomavirus in a population-based study of vulvar cancer.

Current smoking, infection with HPV16, and infection with HSV2 are risk factors for vulvar cancer and risk appears particularly strong among women who are both current smokers and HPV16 seropositive.

A population-based study of squamous cell vaginal cancer: HPV and cofactors.

In situ and invasive vaginal neoplasia have many of the same risk factors as cervical cancer, including a strong relationship to HPV infection.

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

The presence of HPV in virtually all cervical cancers implies the highest worldwide attributable fraction so far reported for a specific cause of any major human cancer, and the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening.

Genital Warts, Other Sexually Transmitted Diseases, and Vulvar Cancer

The results indicate that only a subset of sexually transmitted diseases, particularly human papillomavirus, may play a role in the development of vulvar cancers.

Epidemiology of cancer of the vulva. A case—control study

It is found that environmental exposures may play a role in vulvar carcinogenesis and moderately high odds ratios associated with occupational histories of private household maids and servants, and work in laundry, cleaning, and other garment services.

Cigarette smoking and the risk of anogenital cancer.

The authors' data and those of other investigators suggest that cigarette smoking plays a role in the etiology of anogenital cancers and that smoking has a late-stage or promotional effect.

Epidemiology and etiology of squamous cell carcinoma of the vulva.

  • A. AnsinkA. Heintz
  • Medicine
    European journal of obstetrics, gynecology, and reproductive biology
  • 1993