Risk factors for chronic fatigue syndrome/myalgic encephalomyelitis: a systematic scoping review of multiple predictor studies

  title={Risk factors for chronic fatigue syndrome/myalgic encephalomyelitis: a systematic scoping review of multiple predictor studies},
  author={Susanne Hempel and Duncan Chambers and Anne-Marie Bagnall and Carol Forbes},
  journal={Psychological Medicine},
  pages={915 - 926}
Background The aetiology of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is still unknown. The identification of risk factors for CFS/ME is of great importance to practitioners. Method A systematic scoping review was conducted to locate studies that analysed risk factors for CFS/ME using multiple predictors. We searched for published and unpublished literature in 11 electronic databases, reference lists of retrieved articles and guideline stakeholder submissions in conjunction… 

Potential causal factors of CFS/ME: a concise and systematic scoping review of factors researched

The field of causal hypotheses of CFS/ME is diverse, and it is found that the studies examined all the main categories of possible factors that had been defined a priori.

A logistic regression analysis of risk factors in ME/CFS pathogenesis

The findings are consistent with the increasing body of evidence that has been published about the potential role of infections in the pathogenesis of ME/CFS, including common colds/flu.

Prevalence of and risk factors for severe cognitive and sleep symptoms in ME/CFS and MS

Cognitive and sleep symptoms are more common in myalgic encephalomyelitis/chronic fatigue syndrome patients than in MS patients and healthy controls, providing further support for existing evidence of central nervous system abnormalities in ME/CFS.

Unidentified Chronic Fatigue Syndrome/myalgic encephalomyelitis (CFS/ME) is a major cause of school absence: surveillance outcomes from school-based clinics

Children diagnosed through school-based clinics for chronic fatigue syndrome/myalgic encephalomyelitis are less severely affected than those referred to specialist services and appear to make rapid progress when they access treatment.

Premorbid risk markers for chronic fatigue syndrome in the 1958 British birth cohort.

The importance of premorbid psychopathology in the aetiological pathways of chronic fatigue syndrome/myalgic encephalomyelitis is confirmed, and retrospective findings that childhood adversity may play a role in a minority are replicated.

Comparing specialist medical care with specialist medical care plus the Lightning Process® for chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME): study protocol for a randomised controlled trial (SMILE Trial)

This study will tell us whether adding the LP to SMC is effective and cost-effective compared toSMC alone, and detailed information on the implementation of the LP and SMC.

Adolescent chronic fatigue syndrome: a follow-up study.

About half of the adolescents with CFS had recovered from CFS at follow-up, and the other half was still severely fatigued and physically impaired.

Differences in Physical and Psychosocial Characteristics Between CFS and Fatigued Non-CFS Patients, a Case-Control Study

The results of a multiple logistic regression analysis showed that patients who believe that their fatigue is associated with more severe consequences, thattheir fatigue will last longer and is responsible for more additional symptoms are more likely to be classified as CFS, while patients who are more physically active and have higher levels of “all or nothing behavior” are less likely to being classified as having CFS.

The associated features of multiple somatic symptom complexes.



Epidemiology of chronic fatigue syndrome and self reported myalgic encephalomyelitis in 5-15 year olds: cross sectional study

The prevalence of chronic fatigue, chronic fatigue syndrome, and reported myalgic encephalomyelitis in 5-15 year olds and examined demographic and factors associated with chronic fatigue Syndrome in children are determined.

Interventions for the treatment, management and rehabilitation of patients with chronic fatigue syndrome/myalgic encephalomyelitis: an updated systematic review.

Some behavioural interventions have shown promising results in reducing the symptoms of CFS/ME and improving physical functioning and there is a need for research to define the characteristics of patients who would benefit from specific interventions and to develop clinically relevant objective outcome measures.

The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study

We have developed a conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome. The guidelines cover the clinical and laboratory evaluation of persons

Predictors of fatigue following the onset of infectious mononucleosis

The psycho-behavioural predictors found in this study are amenable to intervention and should be tested in randomized controlled trials.

Childhood predictors of self reported chronic fatigue syndrome/myalgic encephalomyelitis in adults: national birth cohort study

No association was identified between maternal or child psychological distress, academic ability, parental illness, atopy, or birth order and increasing risk of lifetime CFS/ME, and Sedentary behaviour increased the risk.

Development of the chronic fatigue syndrome in severely fatigued employees: predictors of outcome in the Maastricht cohort study

Unexplained fatigue among employees in some instances is a precursor of the development of CFS, and the prognostic role of self rated health suggests that prevention and treatment of chronic fatigue should be aimed at changing the perception of health or illness.

A community-based study of chronic fatigue syndrome.

Earlier findings suggesting that CFS is a syndrome primarily affecting white, middle-class patients were not supported, and the highest levels of CFS were consistently found among women, minority groups, and persons with lower levels of education and occupational status.

Postinfectious fatigue: prospective cohort study in primary care

Early adverse experience and risk for chronic fatigue syndrome: results from a population-based study.

Evidence is provided of increased levels of multiple types of childhood trauma in a population-based sample of clinically confirmed CFS cases compared with nonfatigued controls and results suggest that childhood trauma is an important risk factor for CFS.

Prevalence and incidence of chronic fatigue syndrome in Wichita, Kansas.

Chronic fatigue syndrome constitutes a major public health problem and longitudinal follow-up of this cohort will be used to further evaluate the natural history of this illness.