Risk factors for allergy

  title={Risk factors for allergy},
  author={Liliane F. De Swert},
  journal={European Journal of Pediatrics},
  • L. D. Swert
  • Published 26 January 1999
  • Medicine
  • European Journal of Pediatrics
Host factors involved in the risk for allergy are heredity, sex, race and age, with heredity being by far the most important. Exposure to allergens has been identified as an influential environmental factor, whereas passive smoking and pollution may act as an adjuvant. The atopic mother may – during pregnancy – add to an atopy-prone environment. Whereas respiratory infections are associated with attacks of bronchial asthma, infections in early life might play a role in the protection against… 

Status of Skin Reactivity to Allergens in Parents of Atopic Children and its Relationship with Clinical Characteristics

It is indicated that allergen type that the child is sensitized to does not influence the sensitization frequency in parents, and this difference between clinical and allergic sensitization may be attributed to environmental factors.

Influence of Pollen Grains in Allergic Diseases

Allergic individuals should be particularly careful, consult with allergists and adapt their lifestyle through the application of simple protective measures, and provide doctors with a lot of technological support to diagnose allergic diseases and ongoing therapy.

Factores de riesgo para el desarrollo de asma y otras enfermedades alérgicas

Recognition of the risk factors for allergy is important in order to select the factors that could be modified for individuals at risk and inorder to identify those factors of which the modulation could evolve in general preventive measures.

Is allergenic similarity predictable in respiratory allergies?

Whether or not first degree relatives with respiratory allergies are more likely to be skin test positive to the same allergen extracts as unrelated patients is determined.


Many studies have been performed which indicate that probiotics can temporarily modify the composition of gut microbiota, and potentially these can reduce susceptibility to allergy, leading to health benefits for the host.

Genetic factors in the treatment of bronchial asthma

Since intervention with asthma-causing gene products may not be sufficient for the treatment of this disease, identification of therapy-responsive genes should become more important in the near future.

Hypersensitive Allergic Reactions Caused by Pollen abundantly found in Air during the spring and Autumn Seasons: A case study

The detailed information on indigenous pollen will surely be very useful in diagnosis and management of allergic patients and may immensely help the physicians of the area in treating the patients suffering with various hypersensitive allergic disorders.

Hypersensitive allergic reactions are caused by Pollen abundantly found in air during the spring and autumn seasons

The detailed nformation on indigenous pollen will surely be useful in diagnosis and management of allergic pati ents and may immensely help the physicians of the area in treating the patients suffering with variou s hypersensitive allergic disorders.

Allergen Skin Test Reaction Patterns in Children (≤10 Years Old) from Atopic Families Suggest Age-Dependent Changes in Allergen-IgE Binding in Early Life

The results suggest that atopy-specific physiological mechanisms, primarily those involving allergen-IgE binding, change during the earliest years of life.

Analyses of IgE-epitope profiles from legume allergens as approach towards the development of novel diagnostic and therapeutic reagents in food allergy

Whether peptides may serve as additional or alternative reagents in the in vitro diagnosis of legume allergy is determined and the influence of post-translational hydroxylation of proline residues in peanut Ara h 2 on the capacity to bind serum IgE and thus on the diagnostic value was additionally investigated on the peptide level.



Immune responses during pregnancy and the development of allergic disease.

The immune response of infants born to families with a strong history of allergic disease is relatively immature at birth in comparison to infants with no family history of allergies, so it seems logical that the interaction of these two factors must be important in the ontogeny of allergy disease.

Parental smoking, breast feeding, and respiratory infection in development of allergic diseases.

Advice to families about reduction of environmental allergens continues to pose problems, but parents should be advised to avoid smoking in the child's presence.

Role of viral infections in the inception of asthma and allergies during childhood: could they be protective?

Two articles in this issue of Thorax compare the prevalence of asthma in different population samples and find significantly lower prevalence rates of asthma and allergic sensitisation in Chinese children living in mainland China than in children of similar origin living in westernised Hong Kong.

Atopic versus infectious diseases in childhood: a question of balance?

  • P. HoltP. SlyB. Björksién
  • Biology, Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 1997
It is hypothesized that one of the most potent sources of stimulation is provided by the normal commensal flora of the gasirointesiinal tract, which is establish during early infancy, and generalised contact with the microbial environment plays an obligatory role in stimulating the functional maturation of the Th‐1 arm of the immune response.

The Inverse Association Between Tuberculin Responses and Atopic Disorder

There was a strong inverse association between delayed hypersensitivity to Mycobacterium tuberculosis and atopy among Japanese schoolchildren and positive tuberculin responses predicted a lower incidence of asthma, lower serum IgE levels, and cytokine profiles biased toward TH1 type.

A genetic-epidemiologic study of human immune responsiveness to allergens in an industrial population. III. Environmental influences on skin sensitivity and total serum IgE in a stratified random sample.

The analyses, which simultaneously evaluated the effects of age, sex, Allergy Index and smoking history on log[total IgE]levels, did not support other studies which concluded that smoking significantly increases total serum IgE levels.

The influence of exposure to house dust mite, cat, pollen and fungal allergens in the home on primary sensitisation in asthma

There was a strong indication that the presence of a cat at birth was linked with a higher risk of development of allergy to cat, but high levels of Fel d 1 were sometimes found in homes even when there was no cat present, indicating that allergen may be introduced from other sources.

Maternal inheritance of atopic IgE responsiveness on chromosome 11 q

Atopy in childhood. I. Gender and allergen related risks for development of hay fever and asthma

In both sexes, risk of asthma was primarily associated with sensitization to indoor allergens (house dust mite and cat), and was related to the magnitude of the skin‐test response, while the risk of hay fever was primarilyassociated with grass pollen sensitivity.

Atopic disease and immunoglobulin E in twins reared apart and together.

Maximum-likelihood tests of genetic and environmental components of the variation of total IgE levels revealed a substantial genetic component and a negligible contribution from common familial environmental effects in MZ and DZ twins reared apart or together.