Risk factors and prevention of cardiotoxicity induced by 5-fluorouracil or capecitabine

@article{Jensen2005RiskFA,
  title={Risk factors and prevention of cardiotoxicity induced by 5-fluorouracil or capecitabine},
  author={S\oren Astrup Jensen and Jens Benn S\orensen},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2005},
  volume={58},
  pages={487-493}
}
Aim: 5-Fluorouracil (5-FU) and its prodrug capecitabine are cardiotoxic. This retrospective study aimed to identify risk factors and to give practical measures to make such chemotherapy feasible if cardiotoxicity occur. Method: Review of cardiotoxicity among 668 patients treated with 5-FU or capecitabine for gastrointestinal cancers. Results: Cardiotoxicity occurred in 29 cases (4.3%). The number of cases according to cardiotoxicity CTC grades 2–4 for patients with and without pre-existing… CONTINUE READING