Risk assessment, prediction and prevention of type 1 diabetes.

@article{Harrison2001RiskAP,
  title={Risk assessment, prediction and prevention of type 1 diabetes.},
  author={Leonard C. Harrison},
  journal={Pediatric diabetes},
  year={2001},
  volume={2 2},
  pages={71-82}
}
Circulating antibodies to pancreatic beta-cell antigens are markers of islet autoimmunity. In first-degree relatives of persons with type 1 diabetes, the levels and range of antigen specificities of these islet antibodies reflect the risk for clinical diabetes. However, in the general population, in which the disease prevalence is up to 30-fold lower, the predictive value of islet antibodies is correspondingly less. Islet antibody assays are primarily research tools to identify 'prediabetic… CONTINUE READING
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