Risk and resilience markers in bipolar disorder: brain responses to emotional challenge in bipolar patients and their healthy siblings.

@article{Krueger2006RiskAR,
  title={Risk and resilience markers in bipolar disorder: brain responses to emotional challenge in bipolar patients and their healthy siblings.},
  author={Stephanie Krueger and Martin Alda and Lionel Trevor Young and Kim Goldapple and Saghar Parikh and Helen S. Mayberg},
  journal={The American journal of psychiatry},
  year={2006},
  volume={163 2},
  pages={
          257-64
        }
}
OBJECTIVE The authors previously identified depression-specific differences in brain responses to an emotional challenge in patients with bipolar and unipolar mood disorder. In this study, potential markers of bipolar risk and resilience were examined in a new cohort of lithium-responsive bipolar patients and their healthy siblings. METHOD Changes in regional cerebral blood flow (rCBF) were measured with [(15)O]water positron emission tomography after induction of transient sadness in nine… CONTINUE READING
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