Risk and benefit evaluation in development of pharmaceutical products.

@article{Aaron1993RiskAB,
  title={Risk and benefit evaluation in development of pharmaceutical products.},
  author={C. S. Aaron and Philip R. Harbach and S S Mattano and J. K. Mayo and Y. Wang and R L Yu and David M. Zimmer},
  journal={Environmental Health Perspectives},
  year={1993},
  volume={101},
  pages={291 - 295}
}
Pharmaceutical products are intended to cure disease, reduce pain and suffering, prolong life, and correct metabolic deficits in patients. However, the potential patient population is intrinsically genetically heterogenous, and this factor complicates the evaluation of data on all aspects of safety evaluation of new drugs. Often the genetic heterogeneity is related to drug metabolizing capacity, but recent evidence suggests that heterogeneity in repair capacity as well as structural integrity… 
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