Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome.

@article{Sanz2010RiskadaptedTO,
  title={Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome.},
  author={Miguel Angel Sanz and P Montesinos and Chelo Ray{\'o}n and Alexandra Holowiecka and Javier de la Serna and Gustavo A. Milone and Elena de Lisa and Salut Brunet and Vicente Rubio and Jos{\'e} Mar{\'i}a Ribera and Concha Rivas and Isabel Krsnik and Juan Miguel Bergua and Jose Mari Pastor Gonz{\'a}lez and Joaqu{\'i}n D{\'i}az-Mediavilla and Rafael R. Rojas and F{\'e}lix Manso and Gert Jan Ossenkoppele and Jos{\'e} David Gonz{\'a}lez and Bob Lowenberg},
  journal={Blood},
  year={2010},
  volume={115 25},
  pages={5137-46}
}
A risk-adapted strategy based on all-trans retinoic acid (ATRA) and anthracycline monochemotherapy (PETHEMA LPA99 trial) has demonstrated a high antileukemic efficacy in acute promyelocytic leukemia. We designed a new trial (LPA2005) with the objective of achieving stepwise improvements in outcome. Between July 2005 and April 2009, low- and intermediate-risk patients (leukocytes < 10 x 10(9)/L) received a reduced dose of mitoxantrone for the second consolidation course, whereas high- risk… CONTINUE READING
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A proportional hazards model for the subdistribution of a competing risk

  • J Fine, RJ Gray
  • J Am Stat Assoc
  • 1999
Highly Influential
2 Excerpts

Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation: results of the AIDA-2000 trial of the Italian GIMEMA group

  • F Lo-Coco, G Avvisati, M Vignetti
  • Blood (ASH Annual Meeting Abstracts)
  • 2004

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