Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial

@article{Vaidya2014RiskadaptedTI,
  title={Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial},
  author={J S Vaidya and Frederik Wenz and Max Bulsara and Jeffrey S. Tobias and David John Joseph and Mohammed Keshtgar and Henrik Lavlund Flyger and Samuele Massarut and Michael D. Alvarado and Christobel Saunders and Wolfgang Eiermann and Marinos G. Metaxas and Elena Sperk and Marc Wolf S{\"u}tterlin and Douglas L. Brown and Laura Esserman and Mario Roncadin and Alastair Thompson and John A. Dewar and Helle M R Holtveg and Steffi U. Pigorsch and Mary Falzon and Eleanor Harris and April M Matthews and Chris Brew-Graves and Ingrid Potyka and Tammy Corica and Norman R. Williams and Michael Baum},
  journal={The Lancet},
  year={2014},
  volume={383},
  pages={603-613}
}
BACKGROUND The TARGIT-A trial compared risk-adapted radiotherapy using single-dose targeted intraoperative radiotherapy (TARGIT) versus fractionated external beam radiotherapy (EBRT) for breast cancer. We report 5-year results for local recurrence and the first analysis of overall survival. METHODS TARGIT-A was a randomised, non-inferiority trial. Women aged 45 years and older with invasive ductal carcinoma were enrolled and randomly assigned in a 1:1 ratio to receive TARGIT or whole-breast… CONTINUE READING
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