Risk Management in Tianeptine Abuse in Turkey: A National Experience

  title={Risk Management in Tianeptine Abuse in Turkey: A National Experience},
  author={Nedim Durmus and Gamze Ozbilen and Yelda Kasap and Oğuzhan Koyuncu and Osman Yildirim and Guven Artiran and Saim Kerman and Demet Aydinkarahaliloglu},
  journal={Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology},
OZET: Turkiye'de tianeptinin kotuye kullanim risk yonetimi: Ulusal bir tecrube Amac: Major depresif ataklarin tedavisinde kullanilan tianeptin, herhangi bir ilac veya alkol bagimliligi veya kotuye kullanimi oykusu olanlarda bagimlilik potan- siyeli olan ve yapisal olarak trisiklik antidepresanlara benzerlik gosteren, ancak farmakolojik olarak farkli ozelliklere sahip bir ilactir. Bu calismada, Turkiye'de tianeptinin kotuye kullanim potansiyelinden dogan guvenlik problemlerini ve alinan risk… 

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Tianeptine: An Atypical Antidepressant with Multimodal Pharmacology

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Characteristics of Tianeptine Exposures Reported to the National Poison Data System — United States, 2000–2017

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Caution should be taken when considering the prescription of tianeptine to patients with prior history of substance abuse, and close monitoring for drug misuse is needed during the treatment period.



[A case of tianeptine abuse].

The effect of tianeptine and its addiction risk at the patient who had a history of addiction to multiple substances, and spontaneously increased dose of tIANeptine during the last one year up to 3000 mg per day at present is concluded.

Is it possible to be dependent to Tianeptine, an antidepressant? A case report

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The antidepressant efficacy and favourable tolerability and pharmacokinetic profiles of tianeptine in patients with depression, including those with associated anxiety, have been proven and the data indicate that it may have additional potential in specific subgroups of depressed patients such as the elderly and those with chronic alcoholism.

Efficacy, tolerability and safety of tianeptine in special populations of depressive patients.

The study showed that tianeptine had good efficacy in treatment of mild to moderate forms of depression in special populations of depressive patients (elderly population and patients with comorbid alcohol addiction).

Tianeptine: a novel atypical antidepressant that may provide new insights into the biomolecular basis of depression.

In reliable animal models of depression tianeptine has been shown to prevent neurodegeneration and decreases in hippocampal volume in response to chronic stress, and provides further support for the hypothesis that depression may involve dysregulation of pathways controlling cellular resilience and that treatment should be directed towards the reversal thereof.

Long-Term Administration of Tianeptine in Depressed Patients after Alcohol Withdrawal

The results of this study indicate that tianeptine appears to have the potential to be a safe antidepressant, which might be particularly useful in those patients who are susceptible to the side-effects of psychotropic drugs.

Sertraline, escitalopram and tianeptine related abnormal movements but not with bupropion: A case report

[Abuse of tianeptine. A case report].

A withdrawal syndrome marked by myalgia, and cold feeling was transient, and alleviated by sedative phenothiazine (cyamemazine) and myorelaxant benzodiazepine (tetrazepam).