Risk Factors of Vasopressor-Induced Symmetrical Peripheral Gangrene

@article{Kwon2018RiskFO,
  title={Risk Factors of Vasopressor-Induced Symmetrical Peripheral Gangrene},
  author={Jung Woo Kwon and Min Ki Hong and Bo Young Park},
  journal={Annals of Plastic Surgery},
  year={2018},
  volume={80},
  pages={622 - 627}
}
Background Symmetrical peripheral gangrene (SPG) is an uncommon syndrome showing symmetrical gangrene in acral regions without evidence of large-vessel occlusion or vasculitis. Intravenous vasopressors are frequently used to manage hemodynamically unstable patients. There have been few reports about SPG after using inotropics. However, risk factors for SPG have not been extensively studied. Therefore, the objective of this study was to analyze several cases of SPG and identify risk factors for… 
Botulinum Toxin in the Treatment of Vasopressor-associated Symmetric Peripheral Gangrene
TLDR
Clinicians may consider this local therapy in the treatment of vasopressor-associated symmetric peripheral gangrene, which has been demonstrated to attenuate the release of multiple vasoconstrictive factors that impact vascular smooth muscle and modulate calcium and nitric oxide when injected locally.
Sildenafil for Treating Peripheral Ischemia and Gangrene: A Case Report and Review
TLDR
Systemic sildenafil shows great potential in ameliorating peripheral ischemia and gangrene as an off-label drug of choice in patients with sepsis or shock and in the current literature.
Safety and efficacy of peripheral versus centrally administered vasopressor infusion: A single-centre retrospective observational study.
Analysis of characteristics of peripheral arterial ischemia in premature babies and effects of nitroglycerin patch application
TLDR
Based on a review of the authors' experiences with nitroglycerin patches, it is recommended closely observing skin color and using nitrogoglyin patches on the skin to help improve flow in premature infants with peripheral arterial ischemia.
Incidence and associated risk factors for limb amputation among sepsis survivors in South Korea
TLDR
The incidence of limb amputation was higher among the sepsis survivors having some underlying diseases (DM and peripheral arterial diseases) or receiving certain vasopressor treatments (epinephrine and dopamine).
PRACTIC E Sepsis in Critical Care
)) AND (("2011"[Date Publication] : "2021"[Date Publication])) with filters Clinical study and Age 80+
One Sepsis Fits All ? Are There Different Phenotypes of Sepsis ? Diagnostic Approaches and Therapies
)) AND (("2011"[Date Publication] : "2021"[Date Publication])) with filters Clinical study and Age 80+

References

SHOWING 1-10 OF 25 REFERENCES
Successful resolution of symmetrical peripheral gangrene after severe acute pancreatitis: a case report
TLDR
This is the first case report of symmetrical peripheral gangrene occurring after acute pancreatitis with successful resolution, and the importance of prompt and aggressive fluid resuscitation and consideration of multiple treatment options to prevent a hypovolemic state caused by acute Pancreatitis is highlighted.
Postpartum Peripheral Symmetrical Gangrene: A Case Report
TLDR
Although postpartum period is of high risk for sepsis and use of ergot alkaloids is common in labor but occurrence of peripheral symmetrical gangrene is rare, a high index of suspicion for the diagnosis and timely intervention will prevent irreparable damage and loss of limb.
Symmetrical peripheral gangrene and disseminated intravascular coagulation.
TLDR
Review of the medical literature shows a high association between SPG and DIC, and Symmetrical peripheral gangrene should be considered a cutaneous marker of DIC.
Symmetrical peripheral gangrene: a prospective study of 14 consecutive cases in a tertiary‐care hospital in eastern India
TLDR
Lack of any prospective study on the profile and outcome of patients with SPG prompted this work to undertake the present work.
Symmetrical peripheral gangrene and the use of systemic hyperbaric oxygen therapy.
TLDR
This case report supports the view that early amputation should be avoided allowing for stabilisation of the gangrene so that no viable tissue is sacrificed and further research is necessary to establish the pathogenesis and suitable treatment pathways.
Symmetrical peripheral gangrene: association with noradrenaline administration
TLDR
In all four patients with bilateral pedal ischaemia the syndrome developed in association with noradrenaline administration, sepsis and DIC, despite a high cardiac output and a low calculated systemic vascular resistance index.
Case Reports : Skin Necrosis after High Dose Vasopressor Infusion in Septic Shock
TLDR
2 cases of severe skin necrosis after high dose vasopressor infusion to maintain the recommended MAP in septic shock are reported, which required amputations in both cases.
Symmetrical peripheral gangrene: a rare but dreadful complication of sepsis.
  • M. Parmar
  • Medicine
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
  • 2002
TLDR
A 31-year-old woman presented to the hospital with a 3-week history of malaise and dyspnea and laboratory testing indicated that she had renal failure, which led to elevated creatinine and urine sediment.
Skin Necrosis after a Low-Dose Vasopressin Infusion through a Central Venous Catheter for Treating Septic Shock
TLDR
Although low-dose vasopressin can control hypotension in septic shock patients, low- doses must be used with caution because ischemic complications such as skin necrosis can develop even with administration through a central venous catheter.
Avoidance of vascular complications associated with the use of dopamine
TLDR
Should extravasation occur, prompt infiltration of the area with phentolamine and a local anaesthetic, local cooling and regional sympathetic block may reduce the damage and administration through a catheter placed into a large vein is recommended.
...
...