Risk Factors for Spontaneous Abortion in Early Symptomatic First-Trimester Pregnancies

  title={Risk Factors for Spontaneous Abortion in Early Symptomatic First-Trimester Pregnancies},
  author={Clarisa Gracia and Mary D. Sammel and Jesse L. Chittams and Amy C Hummel and Alka Shaunik and Kurt T. Barnhart},
  journal={Obstetrics \& Gynecology},
OBJECTIVE: To evaluate the association of an ultimate diagnosis of miscarriage with various clinical symptoms and historical factors in a cohort of women presenting with pain, bleeding, or both in the first trimester of pregnancy. METHODS: This was a case–control study from a population of women presenting for care with pelvic pain or vaginal bleeding in the first trimester of pregnancy whose diagnoses were not definite upon initial evaluation. Analyses were performed in 2 ways. In one instance… 

Fetal loss in symptomatic first-trimester pregnancy with documented yolk sac intrauterine pregnancy.

Selected non-somatic risk factors for pregnancy loss in patients with abnormal early pregnancy.

A significant impact on the risk of miscarriage was observed in case of such factors as: exposure to stress at home and limited number of hours of nightly sleep in the studied population of women with abnormal early pregnancy course.

Prediction of outcome in women with symptomatic first-trimester pregnancy: focus on intrauterine rather than ectopic gestation.

Information collected at initial presentation from women at risk for EP to be used for building prediction rules should focus on differentiating a viable from a nonviable pregnancy rather than attempting to distinguish an extrauterine from an intrauterine pregnancy.

A prospective study of risk factors for first trimester miscarriage in Asian women with threatened miscarriage.

Older pregnant women experiencing a threatened miscarriage should be counselled about their higher risk of miscarriage, especially if they have an older partner, the study showed.

First trimester spontaneous abortion: a clinicopathological view

Hematological profile and serum malondialdehyde show no significant difference between abortion cases and those with normal first trimester pregnancy, but the malondialsdehyde level have a strong statistical relation with trophoblastic villous diameter indicating the possibility of underlying relationship between oxidant injury and villousiameter leading to hydropic or even molar changes.

Factors associated with miscarriage and perinatal mortality in women with HIV infection

Action aimed at eliminating drug use during pregnancy, ensuring adequate prenatal care, performing elective cesarean section delivery, and using antiretroviral medications during labor should be prioritized to reduce the rates of miscarriage and perinatal mortality in HIV-infected pregnant women.

Association Between First-Trimester Vaginal Bleeding and Miscarriage

Heavy bleeding in the first trimester, particularly when accompanied by pain, is associated with higher risk of miscarriage, and spotting and light episodes are not, especially if lasting only 1–2 days.

The predictive efficacy of maternal serum CA125 in intrauterine early pregnancy with vaginal bleeding

Using receiver-operating characteristic curve, 150 U/mL of serum CA125 was the most useful value for predicting spontaneous abortion in early pregnancy with vaginal bleeding, and in most of abortion women, the serumCA125 level was increased over than 150U/mL immediately before the abortion.



Determinants of Risk of Spontaneous Abortions in the First Trimester of Pregnancy

A hospital case‐control study to analyze risk factors for spontaneous abortion during the first trimester found a history of pelvic inflammatory disease increased the odds ratio fivefold and women reporting previous spontaneous abortions had a higher chance of having a spontaneous abortion.

Risk factors for spontaneous abortion and its recurrence.

The levels of risk of miscarriage found in this analysis are similar to those of previous studies, and the analytic methods suggest how age, obstetric history, and other factors can be simultaneously examined for associations with such risk.

Threatened abortion: prediction of viability based on signs and symptoms.

The clinical assessment of threatened abortion is unreliable in most cases and should be superseded by ready access to sonographic assessment.

Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case-control, population-based study in France.

This case-control study was associated with a regional register of ectopic pregnancy between 1993 and 2000 in France and was powerful enough to investigate all ectopicregnancy risk factors, finding close associations between ectopic pregnancies and infertility and between spontaneous abortions and spontaneous abortion.

Prompt Diagnosis of Ectopic Pregnancy in an Emergency Department Setting

A protocol of quantitative hCG levels (available within hours of presentation to an emergency department) combined with transvaginal ultrasound is effective in diagnosing ectopic pregnancy.

Infertility and early pregnancy loss.

Induced Abortion as a Risk Factor for Subsequent Fetal Loss

A case‐control study with 331 cases of first spontaneous abortion and 993 controls with no previous spontaneousabortion and a normal pregnancy at the same period of pregnancy reports the relation between past induced abortions and subsequent fetal loss is still unclear.

Association of induced abortion with subsequent pregnancy loss.

It is concluded that multiple induced abortions do increase the risk of subsequent pregnancy losses up to 28 weeks' gestation.

Infectious processes: an infrequent cause of first trimester spontaneous abortions.

The prospective data suggest that the attributable risk of infection in first trimester spontaneous abortion is small and no clinical evidence that infection occurred more often in the 116 subjects experiencing pregnancy loss as compared to the 702 having successful pregnancies.

[Clinical features of missed abortion].

The obtained results confirm that the onset of vaginal bleeding does not reflect the moment of embryonal/fetal death and the reverse correlation was established between the gravidity of a patient and the period of asymptomatic retention of the non-viable conception products in uterus.