Risk Factors for Gallbladder Cancer and Cholangiocarcinoma: Similarities, Differences and Updates

  title={Risk Factors for Gallbladder Cancer and Cholangiocarcinoma: Similarities, Differences and Updates},
  author={Tarun Rustagi and Constantin A. Dasanu},
  journal={Journal of Gastrointestinal Cancer},
IntroductionFar-ranging variation in the incidence of gallbladder cancer (GBC) and cholangiocarcinoma (CCA) in different geographic regions on the globe may reflect the risk factor distribution for these tumorsMethodsThe authors give a comprehensive review on the known risk factors for GBC and CCA, and analyze both similarities and differences between the risk factors for the two main types of biliary cancerDiscussion and ConclusionLeading risk factors for GBC include gallstones, female gender… 

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An overview of the state-of-art in GbCa research is provided with the focus on the current knowledge concerning genetic and environmental triggers of this tumor.

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There is a relationship between gallbladder carcinoma and chronic inflammatory disease of thegallbladder, including xanthogranulomatous cholecystitis, and chronic sclerosing and hyalinizing choleCystitis with or without calcification is associated with gallbladders carcinoma.

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Risk factors for cholangiocarcinoma

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  • Medicine
    European journal of gastroenterology & hepatology
  • 2007
The study by Ahrens et al. finds that obesity and gallstones are risk factors for developing extrahepatic cholangiocarcinoma in men patients and the association of obesity with the risk of developing cholangsiocARCinoma persisted for all anatomic subsites.

Risk factors for biliary tract carcinogenesis.

  • R. Chapman
  • Medicine
    Annals of oncology : official journal of the European Society for Medical Oncology
  • 1999
Cholangiocarcinoma has a worldwide distribution which accounts for about 10-15% of all cases of primary hepatobiliary malignancy and has been weakly linked to hepatitis C infection.

Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study.

  • T. WelzelB. Graubard K. McGlynn
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    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2007

A Case-Control Assessment of Risk Factors for Gallbladder Carcinoma

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Gallbladder cancer worldwide: Geographical distribution and risk factors

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Incidence and Risk Factors for Cholangiocarcinoma in Primary Sclerosing Cholangitis

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Risk Factors for Intrahepatic and Extrahepatic Cholangiocarcinoma: A Hospital-Based Case–Control Study

Liver cirrhosis and chronic HCV infection are possible risk factors for ICC but not ECC, and heavy alcohol consumption is a risk factor for both ICC and ECC.

Risk factors for intrahepatic cholangiocarcinoma: a case-control study in China.

It is suggested that HBV infection and hepatolithiasis are strong risk factors for development of ICC in China.

Epidemiologic aspects of gallbladder cancer: a case-control study of the SEARCH Program of the International Agency for Research on Cancer.

A large, collaborative, multicenter, case-control study of cancer of the gallbladder was conducted in Australia, Canada, The Netherlands, and Poland from January 1983 through July 1988, and findings are consistent with a major role ofgallstones, or risk factors for gallstones, in the cause ofgallbladder cancer.