Risk Factors for Birth Defects.

@article{Harris2017RiskFF,
  title={Risk Factors for Birth Defects.},
  author={Benjamin S. Harris and Katherine Bishop and Hanna R. Kemeny and Jennifer S. Walker and Eleanor H J Rhee and Jeffrey A. Kuller},
  journal={Obstetrical \& gynecological survey},
  year={2017},
  volume={72 2},
  pages={
          123-135
        }
}
Importance Major congenital abnormalities, or birth defects, carry significant medical, surgical, cosmetic, or lifestyle consequences. Such abnormalities may be syndromic, involving multiple organ systems, or can be isolated. Overall, 2% to 4% of live births involve congenital abnormalities. Risk factors for birth defects are categorized as modifiable and nonmodifiable. Modifiable risk factors require thorough patient education/counseling. The strongest risk factors, such as age, family history… 
View on PubMed
betterhealth.vic.gov.au
88 Citations
Highly Influential Citations
3
Background Citations
29
Results Citations
1

88 Citations

Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children’s Study

Maternal low-to-moderate alcohol consumption during pregnancy, even in early pregnancy, displayed no significant adverse impact on congenital heart defects, male genital abnormalities, limb defects, orofacial clefts, severe brain abnormalities, or gastrointestinal obstructions.

Prevalence and factors associated with congenital malformations in live births

The variables pointed out in the study integrated a predictive model that can help in the planning of health services, suggest hypotheses regarding etiological factors, and form prenatal care actions with attention to the identifi ed factors.

Bariatric surgery and the risk of congenital anomalies in subsequent pregnancies.

Having bariatric surgery was a risk factor for birth defects, and particularly heart and musculoskeletal defects, after fortification, however, an association was no longer present.

Prevention and awareness of birth defects across the lifespan using examples from congenital heart defects and spina bifida

The clinical and public health communities have begun to expand their mission and activities to include a focus not only on surveillance during pregnancy/infancy and primary prevention opportunities, but also on the needs of children, adolescents and adults and secondary prevention that can support the health and well-being of individuals living with birth defects across the lifespan.

Future risk of cancer in women who have children with birth defects.

Bariatric surgery and birth defects: A systematic literature review

Study of the association between bariatric surgery and birth defects vary with respect to the surgical procedures included, birth defects ascertainment methods and approaches used to account for maternal BMI, so it is not possible to draw a conclusion.

Inflammatory bowel disease and risk of birth defects in offspring.

Findings suggest that inflammatory bowel disease is associated with the risk of abdominal wall and central nervous system defects, and that introduction of immunobiologic medications is unlikely to be associated with added risk.

Prenatal exposure to criteria air pollutants and associations with congenital anomalies: A Lebanese national study.

Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review

Both PGDM and GDM may cause various motor and behavioral neurodevelopmental problems, including an increased incidence of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).

Risk Assessment for Birth Defects in Offspring of Chinese Pregnant Women

A nomogram risk model for any type of birth defect in a Chinese population based on important modifying factors in pregnant women is developed and could be a tool for clinicians to assess the risk of birth defects and promote health education.
...

References

SHOWING 1-10 OF 103 REFERENCES

Risk of congenital heart defects in the offspring of smoking mothers: a population-based study.

Maternal body mass index and lifestyle exposures and the risk of bilateral renal agenesis or hypoplasia: the National Birth Defects Prevention Study.

The need for further exploration into the potential mechanisms by which maternal smoking, smoking, alcohol, and caffeine exposures could interfere with early fetal kidney formation resulting in RA/H is supported.

Urgent global opportunities to prevent birth defects.

Statement on Guidance for Genetic Counseling in Advanced Paternal Age

Given the wide range of genetic diseases which may be related to advanced paternal age, there is currently no single test available for prenatal screening or diagnosis and prospective couples should receive individualized genetic counseling to address specific concerns.

Maternal Age and Malformations in Singleton Births

Prenatal Alcohol Exposure and Risk of Birth Defects

A fourfold increased risk of birth defects classified as ARBDs was observed after heavy PAE in the first trimester; large, population-based studies are needed to strengthen the evidence base for AR BDs.

Maternal exposure to statins and risk for birth defects: A case‐series approach

The authors proposed that offspring of mothers exposed to lipophilic statins might be at increased risk for holoprosencephaly, limbdeficiencies, and VACTERL defects.

Paternal age and birth defects: how strong is the association?

Infants born to older fathers have a slightly increased risk of birth defects and young paternal age is also associated with slightly increasedrisk of several selected birth defects in their offspring.

Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis.

Maternal obesity is associated with an increased risk of a range of structural anomalies, although the absolute increase is likely to be small.

A case-control study of maternal smoking and congenital malformations.

It is concluded that maternal smoking during pregnancy is associated with an increased risk for some malformations, including microcephalus, cleft defects, and club foot.
...