Risk-Conferring Glutamatergic Genes and Brain Glutamate Plus Glutamine in Schizophrenia

  title={Risk-Conferring Glutamatergic Genes and Brain Glutamate Plus Glutamine in Schizophrenia},
  author={Juan R. Bustillo and Veena Patel and Thomas R. Jones and Rex E. Jung and Nattida Payaknait and Clifford Qualls and Jos{\'e} M. Ca{\~n}ive and Jingyu Liu and Nora I. Perrone-Bizzozero and Vince D. Calhoun and Jessica A. Turner and Charles Gasparovic},
  journal={Frontiers in Psychiatry},
Background The proton magnetic resonance spectroscopy (1H-MRS) signals from glutamate (or the combined glutamate and glutamine signal—Glx) have been found to be greater in various brain regions in people with schizophrenia. Recently, the Psychiatric Genetics Consortium reported that several common single-nucleotide polymorphisms (SNPs) in glutamate-related genes confer increased risk of schizophrenia. Here, we examined the relationship between presence of these risk polymorphisms and brain Glx… 
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