Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance.

@article{Bohr2008RisingFT,
  title={Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance.},
  author={Vilhelm A. Bohr},
  journal={Trends in biochemical sciences},
  year={2008},
  volume={33 12},
  pages={
          609-20
        }
}
The RecQ helicases are guardians of the genome. Members of this conserved family of proteins have a key role in protecting and stabilizing the genome against deleterious changes. Deficiencies in RecQ helicases can lead to high levels of genomic instability and, in humans, to premature aging and increased susceptibility to cancer. Their diverse roles in DNA metabolism, which include a role in telomere maintenance, reflect interactions with multiple cellular proteins, some of which are… CONTINUE READING
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