Rising HIV-1 viral load set point at a population level coincides with a fading impact of host genetic factors on HIV-1 control.

@article{Manen2011RisingHV,
  title={Rising HIV-1 viral load set point at a population level coincides with a fading impact of host genetic factors on HIV-1 control.},
  author={Dani{\"e}lle van Manen and Luuk A J Gras and Brigitte D M Boeser-Nunnink and Ard I. van Sighem and Irma Maurer and Marga M Mangas Ruiz and Agnes M. Harskamp and Radjin Steingrover and Jan C M Prins and Frank de Wolf and Ang{\'e}lique B van 't Wout and Hanneke Schuitemaker},
  journal={AIDS},
  year={2011},
  volume={25 18},
  pages={
          2217-26
        }
}
OBJECTIVE Heterozygosity for a 32 base pair deletion in the CCR5 gene (CCR5wt/Δ32) and the minor alleles of a single-nucleotide polymorphism in the HCP5 gene (rs2395029) and in the HLA-C gene region (-35HLA-C; rs9264942) has been associated with a lower viral load set point. Recent studies have shown that over calendar time, viral load set point has significantly increased at a population level. Here we studied whether this increase coincides with a fading impact of above-mentioned host genetic… CONTINUE READING

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