Risedronate treatment does not increase microdamage in the canine femoral neck.
@article{Forwood1995RisedronateTD, title={Risedronate treatment does not increase microdamage in the canine femoral neck.}, author={M. Forwood and D. Burr and Y. Takano and D. Eastman and P. N. Smith and J. Schwardt}, journal={Bone}, year={1995}, volume={16 6}, pages={ 643-50 } }
Cortical and trabecular bone from the femoral neck of 24 adult female beagle dogs was examined for microdamage following 2 years of treatment with risedronate (NE-58095). Specimens of the femoral neck, sectioned between the femoral head and the intertrochanteric groove, were bulk stained in 1% basic fuchsin in graded alcohols and embedded in methylmethacrylate. Five transverse sections of 100 microns from each specimen were examined for microdamage and measurement of cortical and trabecular… CONTINUE READING
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References
SHOWING 1-10 OF 15 REFERENCES
Bone remodeling in response to in vivo fatigue microdamage.
- Materials Science, Medicine
- Journal of biomechanics
- 1985
- 697
Changes in bone histomorphometry after long‐term treatment with intermittent, cyclic etidronate for postmenopausal osteoporosis
- Medicine
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- 1993
- 159
Transient effects of subcutaneously administered prostaglandin E2 on cancellous and cortical bone in young adult dogs.
- Chemistry, Medicine
- Bone
- 1990
- 99
Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis.
- Medicine
- The New England journal of medicine
- 1990
- 865
Validity of the bulk-staining technique to separate artifactual from in vivo bone microdamage.
- Medicine
- Clinical orthopaedics and related research
- 1990
- 276
Calculating the probability that microcracks initiate resorption spaces.
- Materials Science, Medicine
- Journal of biomechanics
- 1993
- 143
Effects of ethane-1 hydroxy-1, 1-diphosphonate (5 mg/kg/day dose) on quantitative bone histology in Paget's disease of bone.
- Medicine
- Metabolic bone disease & related research
- 1981
- 48
Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee
- Medicine
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- 1987
- 4,843
- PDF