Risedronate in adults with osteogenesis imperfecta type I: increased bone mineral density and decreased bone turnover, but high fracture rate persists

@article{Bradbury2011RisedronateIA,
  title={Risedronate in adults with osteogenesis imperfecta type I: increased bone mineral density and decreased bone turnover, but high fracture rate persists},
  author={Linda A. Bradbury and Shari Barlow and Finn Geoghegan and Rosemary A Hannon and S L Stuckey and John A. H. Wass and R. Graham G. Russell and Mark A Brown and Emma L. Duncan},
  journal={Osteoporosis International},
  year={2011},
  volume={23},
  pages={285-294}
}
Bisphosphonates can increase bone mineral density (BMD) in children with osteogenesis imperfecta (OI). In this study of adults with OI type I, risedronate increased BMD at lumbar spine (but not total hip) and decreased bone turnover. However, the fracture rate in these patients remained high. Intravenous bisphosphonates given to children with OI can increase BMD and reduce fracture incidence. Oral and/or intravenous bisphosphonates may have similar effects in adults with OI. We completed an… CONTINUE READING
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