Ripe areca nut extract induces G1 phase arrests and senescence-associated phenotypes in normal human oral keratinocyte.

@article{Lu2006RipeAN,
  title={Ripe areca nut extract induces G1 phase arrests and senescence-associated phenotypes in normal human oral keratinocyte.},
  author={Ssu-Yi Lu and Kuo-Wei Chang and Chung-Ji Liu and Yu-Hsin Tseng and H Lu and Suz-Ying Lee and Shu-Chun Lin},
  journal={Carcinogenesis},
  year={2006},
  volume={27 6},
  pages={1273-84}
}
Around 200-600 million Asians chew areca (also called betel), which contains a mixture of areca nut and other ingredients. Epidemiological evidences indicated that areca use is tightly linked to oral carcinogenesis. This study investigated the effects of ripe areca nut extract (ANE) on cultured normal human oral keratinocyte (NHOK). Acute subtoxic ANE treatment inhibited DNA synthesis and induced cell cycle arrest at G1 phase in early passage (< 4th passage) cells. This was accompanied by a… CONTINUE READING