RipA, a cytoplasmic membrane protein conserved among Francisella species, is required for intracellular survival.

@article{Fuller2008RipAAC,
  title={RipA, a cytoplasmic membrane protein conserved among Francisella species, is required for intracellular survival.},
  author={James R. Fuller and Robin R. Craven and Joshua D Hall and Todd M. Kijek and Sharon A. Taft-Benz and Thomas H Kawula},
  journal={Infection and immunity},
  year={2008},
  volume={76 11},
  pages={4934-43}
}
Francisella tularensis is a highly virulent bacterial pathogen that invades and replicates within numerous host cell types, including macrophages and epithelial cells. In an effort to better understand this process, we screened a transposon insertion library of the F. tularensis live vaccine strain (LVS) for mutant strains that invaded but failed to replicate within alveolar epithelial cell lines. One such strain isolated from this screen contained an insertion in the gene FTL_1914, which is… CONTINUE READING