Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching

Abstract

INTRODUCTION Current treatment with vasodilators for pulmonary hypertension associated with respiratory diseases is limited by their inhibitory effect on hypoxic pulmonary vasoconstriction (HPV) and uncoupling effects on ventilation-perfusion (V'/Q'). Hypoxia is also a well-known modulator of the nitric oxide (NO) pathway, and may therefore differentially… (More)
DOI: 10.1371/journal.pone.0191239

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