Rings, chains and ladders: ubiquitin goes to work in the neuron

@article{Johnston2004RingsCA,
  title={Rings, chains and ladders: ubiquitin goes to work in the neuron},
  author={Jennifer A. Johnston and Kiran Madura},
  journal={Progress in Neurobiology},
  year={2004},
  volume={73},
  pages={227-257}
}
Our understanding of neuronal cell biology in the last 10 years has exploded. In parallel, our grasp of basic cellular processes, such as protein synthesis and protein degradation has also grown exponentially. In this review, we provide an in-depth background to details of current knowledge of the Ub/proteasome pathway. We also provide examples of recent experiments in neurobiology that suggest a central role for targeted protein degradation by the Ub/proteasome pathway to ensure proper… CONTINUE READING
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