Ringlike structure of the Deinococcus radiodurans genome: a key to radioresistance?

@article{LevinZaidman2003RinglikeSO,
  title={Ringlike structure of the Deinococcus radiodurans genome: a key to radioresistance?},
  author={Smadar Levin-Zaidman and Joseph Englander and Eyal Shimoni and Ajay Kr. Sharma and Kenneth W. Minton and Abraham Minsky},
  journal={Science},
  year={2003},
  volume={299 5604},
  pages={254-6}
}
The bacterium Deinococcus radiodurans survives ionizing irradiation and other DNA-damaging assaults at doses that are lethal to all other organisms. How D. radiodurans accurately reconstructs its genome from hundreds of radiation-generated fragments in the absence of an intact template is unknown. Here we show that the D. radiodurans genome assumes an unusual toroidal morphology that may contribute to its radioresistance. We propose that, because of restricted diffusion within the tightly… CONTINUE READING
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