Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues.

@article{Monga2004RingsubstitutedQP,
  title={Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues.},
  author={Vikramdeep Monga and Amit Nayyar and Balasubramanian Vaitilingam and Prakash B Palde and Sarbjit Singh Jhamb and Sukhraj Kaur and Prati Pal Singh and Rahul Jain},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 24},
  pages={6465-72}
}
Additional structural modifications of the new chemical entity, 2,8-dicyclopentyl-4-methylquinoline (DCMQ; MIC=6.25 microg/mL, M. tuberculosis H37Rv) resulted in the synthesis of four new series of the ring-substituted quinolinecarbohydrazides (series 1-4) constituting 22 analogues. All new derivatives were evaluated for in vitro antimycobacterial activities against drug-sensitive M. tuberculosis H37Rv strain. Certain ring-substituted-2-quinolinecarbohydrazide analogues described herein showed… CONTINUE READING

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