Ring structure amino acids affect the suppressor activity of melon aphid-borne yellows virus P0 protein.

@article{Han2010RingSA,
  title={Ring structure amino acids affect the suppressor activity of melon aphid-borne yellows virus P0 protein.},
  author={Yan-Hong Han and Hai-ying Xiang and Qian Wang and Yuanyuan Li and Wen-qi Wu and Chenggui Han and Da-wei Li and Jialin Yu},
  journal={Virology},
  year={2010},
  volume={406 1},
  pages={21-7}
}
Melon aphid-borne yellows virus (MABYV) is a newly identified polerovirus occurring in China. Here, we demonstrate that the MABYV encoded P0 (P0(MA)) protein is a strong suppressor of post-transcriptional gene silencing (PTGS) with activity comparable to tobacco etch virus (TEV) HC-Pro. In addition we have shown that the LP F-box motif present at the N-terminus of P0(MA) is required for suppressor activity. Detailed mutational analyses on P0(MA) revealed that changing the conserved Trp 212 with… CONTINUE READING
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