Ring-closing metathesis ( RCM ) reaction : application in the synthesis of cyclopropyl-lactone segment of solandelactones

An efficient synthesis of cyclopropyl-lactone containing fragment of solandelactones has been achieved via ring-closing olefinic metathesis reaction. Grubbs’ second generation RuCl2(=CHPh)(PCy3)(IEMS) catalyst has been successfully and efficiently utilized in the construction of eight-membered lactone ring with cis-double bond present in solandelactones.