Ring chromosome 8 and trisomy 8 in a patient with acute myeloid leukemia

@article{Kar2009RingC8,
  title={Ring chromosome 8 and trisomy 8 in a patient with acute myeloid leukemia},
  author={B. Kar and B. Nandhini and R. Revathi},
  journal={Indian Journal of Hematology and Blood Transfusion},
  year={2009},
  volume={25},
  pages={30-32}
}
  • B. Kar, B. Nandhini, R. Revathi
  • Published 2009
  • Medicine
  • Indian Journal of Hematology and Blood Transfusion
  • We describe a child with Acute Myeloid Leukemia (AML M7) with trisomy 8 and ring chromosome 8. Ring chromosome 8 associated with AML is uncommon and is reported to have a poor outcome. The combination of trisomy 8 and ring chromosome 8 has not been previously reported. This 15-month-old girl had presented with a history of fever, weight loss of 1 kg, gum bleeds and pallor. Clinical examinations revealed no nodes or organomegaly. Investigations revealed pancytopenia and elevated serum LDH. Bone… CONTINUE READING
    3 Citations

    References

    SHOWING 1-10 OF 10 REFERENCES
    MDS and AML with trisomy 8 as the sole chromosome aberration show different sex ratios and prognostic profiles: A study of 115 published cases
    • 42
    Bone marrow karyotype and prognosis in primary myelodysplastic syndromes
    • 61
    Trisomy 4: clinical picture, hematology, and survival. Presentation of two cases and review of the literature.
    • 7
    Survival of patients with t(1;7)(p11;p11). Report of two cases and review of the literature.
    • B. Pedersen
    • Biology, Medicine
    • Cancer genetics and cytogenetics
    • 1992
    • 34
    Anatomy of the 5q- deletion: different sex ratios and deleted 5q bands in MDS and AML.
    • 31
    A factor encoded by 7q31 suppresses expansion of the 7q- clone and delays cytogenetic progression.
    • 28
    Human Cytogenetics: Constitutional analysis, A practical approach
    • 2001