Ring chromosome 8 and trisomy 8 in a patient with acute myeloid leukemia

  title={Ring chromosome 8 and trisomy 8 in a patient with acute myeloid leukemia},
  author={Bibhas Kar and B. Nandhini and R. Revathi},
  journal={Indian Journal of Hematology and Blood Transfusion},
We describe a child with Acute Myeloid Leukemia (AML M7) with trisomy 8 and ring chromosome 8. Ring chromosome 8 associated with AML is uncommon and is reported to have a poor outcome. The combination of trisomy 8 and ring chromosome 8 has not been previously reported. This 15-month-old girl had presented with a history of fever, weight loss of 1 kg, gum bleeds and pallor. Clinical examinations revealed no nodes or organomegaly. Investigations revealed pancytopenia and elevated serum LDH. Bone… Expand
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  • B. Pedersen
  • Biology, Medicine
  • American journal of hematology
  • 1997
In MDS age and in AML the trisomy 8 clonal size was an independent prognostic factor and an unexpected observation was a clear male preponderance in trisome 8 MDS (about two‐thirds of cases). Expand
Trisomy 4: clinical picture, hematology, and survival. Presentation of two cases and review of the literature.
Two patients with acute nonlymphocytic leukemia (ANLL) and trisomy 4 as the only cytogenetic aberration are presented, and the two age groups as well as presence/absence of infection at the time of diagnosis were without significant prognostic consequences. Expand
Bone marrow karyotype and prognosis in primary myelodysplastic syndromes
The findings demonstrate the prognostic importance of quantifying the complexity of bone marrow chromosome changes and emphasize that different specific abnormalities convey widely different prognostic information in primary myelodysplastic syndromes. Expand
Trisomy 13: a preferentially male chromosome aberration interfering specifically with myeloid proliferation and differentiation? Report of a case and review of the literature.
It is suggested that trisomy 13 is a specific nosologic entity with male predominance and characterized by interference with proliferation and differentiation in the myeloid differentiation series. Expand
Survival of patients with t(1;7)(p11;p11). Report of two cases and review of the literature.
  • B. Pedersen
  • Biology, Medicine
  • Cancer genetics and cytogenetics
  • 1992
Despite its relation to earlier chemotherapy, the chromosome aberrations associated with t(1;7) lack the cytogenetic features characteristic of therapy-induced disorders. Expand
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The 5q31 was deleted in all patients with MDS and 5q- as the only aberration, and in AML and following cytogenetic progression other bands were deleted more often than5q31, which suggests diverse pathogenetic mechanisms in M DS and AML. Expand
A factor encoded by 7q31 suppresses expansion of the 7q- clone and delays cytogenetic progression.
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Human Cytogenetics: Constitutional analysis, A practical approach
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