Ring chromosome 4: Wolf syndrome and unspecific developmental anomalies.

@article{Kosztolnyi1985RingC4,
  title={Ring chromosome 4: Wolf syndrome and unspecific developmental anomalies.},
  author={Gy{\"o}rgy Kosztol{\'a}nyi},
  journal={Acta paediatrica Hungarica},
  year={1985},
  volume={26 2},
  pages={157-65}
}
A new case of ring chromosome 4 in a 18-month-old girl is described. The patient presented extreme growth failure, psychomotor retardation, and some features of 4p deletion or Wolf syndrome. No significant loss of genetic material could be seen by G-banding technique (breakpoints p16q35). The ring was found to be unstable both in lymphocyte and fibroblast culture and a substantial proportion of aneuploid cells containing derivatives of the ring could be observed. An increased cell death-rate… CONTINUE READING