Ring a reduced progestins potently stimulate estrous behavior in rats: Paradoxical effect through the progesterone receptor

@article{Beyer1995RingAR,
  title={Ring a reduced progestins potently stimulate estrous behavior in rats: Paradoxical effect through the progesterone receptor},
  author={Carlos Beyer and Oscar Gonz{\'a}lez‐Flores and Gabriela Gonz{\'a}lez-Mariscal},
  journal={Physiology \& Behavior},
  year={1995},
  volume={58},
  pages={985-993}
}
The effect of ring A reductions at C5 and C3 on the capacity of the progesterone (P) molecule to stimulate estrous behavior was studied in ovariectomized estrogen primed rats (5 micrograms estradiol benzoate, EB, 40 h before progestin administration). Dose-response curves (dose range: 0.75-200 micrograms) for the lordosis quotient (LQ), lordosis score (LS), and proceptivity were constructed for P and all its ring A reduced metabolites: 5 alpha-pregnanedione (alpha DHP), 5 beta-pregnanedione… Expand
Ring A Reductions of Progestins Are Not Essential for Estrous Behavior Facilitation in Estrogen-Primed Rats
TLDR
The results suggest that ring A reduction of progestins to 5alpha/5beta metabolites is not essential for the facilitation of estrous behavior in ovx estrogen-primed rats and 3-ketosteroid reduction is also not essential. Expand
GnRH mediates estrous behavior induced by ring A reduced progestins and vaginocervical stimulation
TLDR
The results suggest that GnRH release is an important process in the chain of events leading to the display of estrous behavior in response to progesterone, its ring A-reduced metabolites, and VCS in female rats. Expand
Differential effect of kinase A and C blockers on lordosis facilitation by progesterone and its metabolites in ovariectomized estrogen-primed rats
TLDR
The results suggest that P and its ring A-reduced metabolites stimulate lordosis behavior through different cellular mechanisms: P acting mainly through the cAMP-kinase system; alpha-DHP through both kinase A and kinase C signaling pathways and 5alpha,3alpha-Pgl through the kin enzyme C system. Expand
A role for Src kinase in progestin facilitation of estrous behavior in estradiol-primed female rats
TLDR
The results suggest that progestins act through Src/Raf/MAPK signaling to initiate estrous behaviors in estrogen-primed rats. Expand
Indomethacin Inhibits Lordosis Induced by Ring A-Reduced Progestins: Possible Role of 3α-Oxoreduction in Progestin-Facilitated Lordosis
TLDR
Results suggest that: (a) oxidation is essential for lordosis facilitation by 3alpha-pregnanolones and (b) reduction of 3-keto progestins generates 3 alpha-hydroxy metabolites which synergize with processes triggered by occupation of the PR by 3- keto progESTins. Expand
Estrogen receptors regulate the estrous behavior induced by progestins, peptides, and prostaglandin E2
TLDR
Results suggest that activation of classical ERs participates in the triggering effects on estrous behavior induced by agents with different chemical structures that do not bind directly to ERs. Expand
Role of Progesterone Receptor Isoforms in Female Sexual Behavior Induced by Progestins in Rats
TLDR
It is suggested that the PR-B isoform is essential for the display of the lordosis behavior in rats. Expand
The nitric oxide pathway participates in estrous behavior induced by progesterone and some of its ring A-reduced metabolites
TLDR
The hypothesis that the nitric oxide/cGMP/protein kinase G pathway is involved in the facilitation of sexual behavior induced by P and some of its ring A-reduced metabolites is supported. Expand
Regulation of lordosis by cyclic 3',5'-guanosine monophosphate, progesterone, and its 5alpha-reduced metabolites involves mitogen-activated protein kinase.
TLDR
The hypothesis that the MAPK pathway is involved in lordosis regulation by P and some of its ring A-reduced metabolites as well as by the second messenger, cGMP, is supported. Expand
Progestins and place preference conditioning after paced mating
TLDR
It is suggested that P and ring A-reduced metabolites facilitate the reward state following pacing, which is similar to the state induced when the females are allowed to pace their sexual contacts. Expand
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References

SHOWING 1-10 OF 59 REFERENCES
Intrahypothalamic effects of progestin agonists on estrous behavior and progestin receptor binding
TLDR
It is suggested that neither 5 alpha-reduction nor 20 alpha-hydroxylation are necessary for P activation of estrous responsiveness and that the structural features required for the behavior promoting effects of P may not be identical to those required for binding to brain progestin receptors. Expand
Induction of lordosis behavior in female rats by intravenous administration of progestins
TLDR
The data suggest that 20α-dihydroprogesterone, which is secreted at high levels during the estrous cycle, could play a role in the regulation of sexual receptivity and suggest that 5α-reduction is probably not crucial for progesterone's action. Expand
Actions of progestins on estrous behavior in female rats
TLDR
It is suggested that progesterone and R 5020 facilitate estrous responsiveness through the same mechanism. Expand
Intrahypothalamic injection of RU486 antagonizes the lordosis induced by ring A-reduced progestins
TLDR
Results suggest that ring A-reduced progestins may act through the PR mechanism to facilitate lordosis in estrogen primed rats, i.e., in a fashion similar to P. Expand
Progesterone and 5alpha-reduced metabolites: facilitation of lordosis behavior and brain uptake in female hamsters.
TLDR
5 α -reduction is not an important metabolic step in progesterone facilitation of receptivity in hamsters, and 5-DHP facilitated receptivity only at the highest dosage, and 3-5-P was totally ineffective in stimulating receptivity. Expand
Pregnanolone, a metabolite of progesterone, stimulates LH-RH release: in vitro and in vivo studies
TLDR
In OVX + E2 rats bearing a push-pull cannula (PPC) in the hypothalamic area, in vivo infusion of repetitive pulses of pregnanolone through the PPC was also effective, confirming in vivo the stimulatory effect of pregnanciesolone on LH-RH release obtained from in vitro preparations. Expand
The relevance of hypothalamic and hyphophyseal progestin receptor regulation in the induction and inhibition of sexual behavior in the female rat.
TLDR
In the ovariectomized rat, induction of PR followed the same pattern as induction of lordosis, and the increase in PR after EB priming was lower and in accord with the much higher EB doses required for a lordosis response. Expand
Effects of several pregnane and pregnene steroids on estrous behavior in ovariectomized, estrogen-primed guinea pigs.
TLDR
There was no correlation between the polarity of the steroids tested and their effectiveness in inducing lordosis, and progesterone was far more effective than pregnanedione, and the data indicate that guinea pigs are more behaviorally responsive to progester one than rats. Expand
Comparative facilitation and inhibition of lordosis in the guinea pig with progesterone, 5α-pregnane-3,20-dione, or 3α-hydroxy-5α-pregnan-20-one
Abstract The major 5α-reduced metabolites of progesterone tentatively identified in neural tissue of the guinea pig were evaluated in this species for their ability to facilitate and inhibit lordosisExpand
Facilitation of lordosis behavior in ovariectomized estrogen-primed rats by medial preoptic implantation of 5β, 3β, pregnanolone: A ring A reduced progesterone metabolite
TLDR
The present results show that some 5 beta reduced P metabolites can facilitate with a short latency the display of lordosis behavior, probably by depressing the activity of telencephalic neurons inhibitory to sexual behavior. Expand
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