Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses.

  title={Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses.},
  author={Miyuki Kabayama and Kazuto Sakoori and Kazuyuki Yamada and Veravej G Ornthanalai and Maya Ota and Naoko Morimura and Kei-ichi Katayama and N. P. Murphy and Jun Aruga},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={33 32},
Monoamine oxidase A (MAO-A), the catabolic enzyme of norepinephrine and serotonin, plays a critical role in emotional and social behavior. However, the control and impact of endogenous MAO-A levels in the brain remains unknown. Here we show that the RING finger-type E3 ubiquitin ligase Rines/RNF180 regulates brain MAO-A subset, monoamine levels, and emotional behavior. Rines interacted with MAO-A and promoted its ubiquitination and degradation. Rines knock-out mice displayed impaired stress… CONTINUE READING
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