Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase.

@article{Ogawa2008RinesRNF180AN,
  title={Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase.},
  author={Miyuki Ogawa and Kiyomi Mizugishi and Akira Ishiguro and Yoshio Koyabu and Yuzuru Imai and Ryosuke Takahashi and Katsuhiko Mikoshiba and Jun Aruga},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2008},
  volume={13 4},
  pages={397-409}
}
We identified and characterized a novel RING finger gene, Rines/RNF180, which is well conserved among vertebrates. Putative Rines gene product (Rines) contains a RING finger domain, a basic coiled-coil domain, a novel conserved domain (DSPRC) and a C-terminal hydrophobic region that is predicted to be a transmembrane domain. N-terminally epitope tagged-Rines (Nt-Rines) was detected in the endoplasmic reticulum membrane/nuclear envelope in cultured mammalian cells. Nt-Rines was not extracted by… CONTINUE READING
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