Rimonabant attenuates amphetamine sensitisation in a CCK2 receptor-dependent manner.

@article{Rnkorg2012RimonabantAA,
  title={Rimonabant attenuates amphetamine sensitisation in a CCK2 receptor-dependent manner.},
  author={Kertu R{\"u}nkorg and Laura Orav and Sulev K{\~o}ks and Toshimitsu Matsui and Vallo Volke and E. E. Vasar},
  journal={Behavioural brain research},
  year={2012},
  volume={226 1},
  pages={335-9}
}
In this behavioural and pharmacological study in male CCK2 receptor-deficient mice (CCK2(-/-)), we evaluated the role of the interaction of endocannabinoids (eCBs) and cholecystokinin (CCK) on the regulation of anxiety-related and motor behaviours. Repeated treatment with amphetamine (2mg/kg daily for four days) induced slightly weaker motor sensitisation in CCK2(-/-) mice compared to their wild-type (CCK2(+/+)) littermates. Co-administration of rimonabant (1mg/kg) with amphetamine antagonised… CONTINUE READING