Riluzole suppresses motor cortex facilitation in correlation to its plasma level

@article{Schwenkreis2000RiluzoleSM,
  title={Riluzole suppresses motor cortex facilitation in correlation to its plasma level},
  author={Peter Schwenkreis and Joachim Liepert and Katja Witscher and W C Fischer and Cornelius Weiller and J. -P. Malin and Martin Tegenthoff},
  journal={Experimental Brain Research},
  year={2000},
  volume={135},
  pages={293-299}
}
The aim of our study was to measure the effects of the glutamate antagonist riluzole on different parameters of motor excitability, using transcranial magnetic stimulation (TMS) during 7 days of riluzole administration, and to correlate these effects with riluzole plasma levels. Nine healthy volunteers received a dose of 100 mg riluzole from day 1 to 7 of the study period. Electrophysiological examinations were performed on day 1 before and 2 h, 5 h and 8 h after riluzole administration, on day… CONTINUE READING