Riluzole-sensitive slowly inactivating sodium current in rat suprachiasmatic nucleus neurons.

@article{Kononenko2004RiluzolesensitiveSI,
  title={Riluzole-sensitive slowly inactivating sodium current in rat suprachiasmatic nucleus neurons.},
  author={Nikolai I. Kononenko and Li-Rong Shao and F. Edward Dudek},
  journal={Journal of neurophysiology},
  year={2004},
  volume={91 2},
  pages={710-8}
}
The persistent (i.e., slowly inactivating) fraction of the Na current (I(Na,P)) regulates excitability of CNS neurons. In isolated rat suprachiasmatic nucleus (SCN) neurons with a ramp-type voltage-clamp protocol, we have studied the properties of a robust current that has the general properties of I(Na,P) but exhibits a slow inactivation (I(Na,S)). The time dependence of the development of the inactivation was also studied by clamping of the membrane potential at different levels: time… CONTINUE READING