Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current.

Abstract

BACKGROUND AND PURPOSE Current strategies to ameliorate cardiac ischaemic and reperfusion damage, including block of the sodium-hydrogen exchanger, are therapeutically ineffective. Here we propose a different approach, block of the persistent sodium current (INaP). EXPERIMENTAL APPROACH Left ventricular pressure was measured as an index of functional… (More)
DOI: 10.1111/j.1476-5381.2010.00766.x

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