Riluzole promotes survival of rat motoneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers.

@article{Peluffo1997RiluzolePS,
  title={Riluzole promotes survival of rat motoneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers.},
  author={Hugo Peluffo and Alvaro G. Est{\'e}vez and Luis Barbeito and J. M. Stutzmann},
  journal={Neuroscience letters},
  year={1997},
  volume={228 3},
  pages={207-11}
}
In the present study we have assessed whether riluzole stimulates the production of trophic activities for motoneurons by spinal astrocyte cultures. Astrocyte monolayers prepared from new-born rats were exposed to vehicle or riluzole (1-10 microM) for 30-36 h, then washed and further incubated without riluzole for 24 h in L15 medium to obtain the astrocyte conditioned media (ACM). Motoneuron-enriched cultures were used to test the ability of the ACM to support motoneuron viability. Astrocyte… CONTINUE READING

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