Riluzole inhibits the persistent sodium current in mammalian CNS neurons.

  title={Riluzole inhibits the persistent sodium current in mammalian CNS neurons.},
  author={Alessandra Urbani and Ottorino Belluzzi},
  journal={The European journal of neuroscience},
  volume={12 10},
The effects of 0.1-100 microM riluzole, a neuroprotective agent with anticonvulsant properties, were studied on neurons from rat brain cortex. Patch-clamp whole-cell recordings in voltage-clamp mode were performed on thin slices to examine the effects of the drug on a noninactivating (persistent) Na+ current (INa,p). INa,p was selected because it enhances neuronal excitability near firing threshold, which makes it a potential target for anticonvulsant drugs. When added to the external solution… CONTINUE READING
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